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  4. Recombinant Human F-box/LRR-repeat protein 21 (FBXL21)

Recombinant Human F-box/LRR-repeat protein 21 (FBXL21)

  • 中文名称：
    人FBXL21重组蛋白
  • 货号：
    CSB-YP891953HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人FBXL21重组蛋白
  • 货号：
    CSB-EP891953HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人FBXL21重组蛋白
  • 货号：
    CSB-EP891953HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人FBXL21重组蛋白
  • 货号：
    CSB-BP891953HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人FBXL21重组蛋白
  • 货号：
    CSB-MP891953HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    FBXL21
  • Uniprot No.：
  • 别名：
    F box and leucine rich repeat protein 21; F box and leucine rich repeat protein 3 pseudogene; F box and leucine rich repeat protein 3B; F box protein Fbl3b; F box/LRR repeat protein 21; F box/LRR repeat protein 3B; F-box and leucine-rich repeat protein 21; F-box and leucine-rich repeat protein 3B; F-box/LRR-repeat protein 21; F-box/LRR-repeat protein 3B; Fbl 21; FBL 3; FBL 3B; Fbl21; FBL3; FBL3B; FBXL 21; FBXL 3B; FBXL 3P; Fbxl21; FBXL3B; FBXL3P; FXL21_HUMAN; MGC120237
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-434
  • 氨基酸序列
    MKRNSLSVEN KIVQLSGAAK QPKVGFYSSL NQTHTHTVLL DWGSLPHHVV LQIFQYLPLL DRACASSVCR RWNEVFHISD LWRKFEFELN QSATSSFKST HPDLIQQIIK KHFAHLQYVS FKVDSSAESA EAACDILSQL VNCSIQTLGL ISTAKPSFMN VSESHFVSAL TVVFINSKSL SSIKIEDTPV DDPSLKILVA NNSDTLRLPK MSSCPHVSSD GILCVADRCQ GLRELALNYY ILTDELFLAL SSETHVNLEH LRIDVVSENP GQIKFHAVKK HSWDALIKHS PRVNVVMHFF LYEEEFETFF KEETPVTHLY FGRSVSKVVL GRVGLNCPRL IELVVCANDL QPLDNELICI AEHCTNLTAL GLSKCEVSCS AFIRFVRLCE RRLTQLSVME EVLIPDEDYS LDEIHTEVSK YLGRVWFPDV MPLW
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL21) complex mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY proteins stabilization. The SCF(FBXL21) complex counteracts the activity of the SCF(FBXL3) complex and protects CRY proteins from degradation. Involved in the hypothalamic suprachiasmatic nucleus (SCN) clock regulating temporal organization of the daily activities.
  • 亚细胞定位：
    Cytoplasm, cytosol. Nucleus.
  • 数据库链接：

    HGNC: 13600

    OMIM: 609087

    UniGene: Hs.591275