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  4. Recombinant Human Fas apoptotic inhibitory molecule 1 (FAIM)

Recombinant Human Fas apoptotic inhibitory molecule 1 (FAIM)

  • 中文名称：
    人FAIM重组蛋白
  • 货号：
    CSB-YP889122HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人FAIM重组蛋白
  • 货号：
    CSB-EP889122HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人FAIM重组蛋白
  • 货号：
    CSB-EP889122HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人FAIM重组蛋白
  • 货号：
    CSB-BP889122HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人FAIM重组蛋白
  • 货号：
    CSB-MP889122HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    FAIM
  • Uniprot No.：
  • 别名：
    FAIM 1; Faim; FAIM1; FAIM1_HUMAN; Fas apoptotic inhibitory molecule 1; Fas apoptotic inhibitory molecule
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-179
  • 氨基酸序列
    TDLVAVWDV ALSDGVHKIE FEHGTTSGKR VVYVDGKEEI RKEWMFKLVG KETFYVGAAK TKATINIDAI SGFAYEYTLE INGKSLKKYM EDRSKTTNTW VLHMDGENFR IVLEKDAMDV WCNGKKLETA GEFVDDGTET HFSIGNHDCY IKAVSSGKRK EGIIHTLIVD NREIPEIAS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a role as an inducible effector molecule that mediates Fas resistance produced by surface Ig engagement in B cells.
  • 基因功能参考文献：
    1. the anti-apoptotic effect of SRT1720 was mitigated by FAIM knockdown with a small interfering RNA-targeted FAIM. These results indicated that pretreatment with SRT1720 improves survival of aged hMSCs, and enhances their therapeutic efficacy for rat myocardial infarction (MI). PMID: 28383554
    2. subcellular fractionation experiments revealed that, in contrast to FAIM-S and FAIM-L, FAIM-S_2a and FAIM-L_2a are able to localize to the nucleus, where they may have additional functions. In summary, here we report on two novel FAIM isoforms that may have relevant roles in the physiology and pathology of the nervous system PMID: 28981531
    3. Data indicate that FAIM is a novel regulator of insulin signalling and plays an essential role in energy homoeostasis. PMID: 26866272
    4. FAIM modulates IGF-1-induced Akt activation and IRF4 expression and has a role in multiple myeloma cell survival PMID: 23138182
    5. FAIM (1-90) was crystallized and diffracted to a resolution of 2.5 A; the crystal belonged to space group P3(1), with unit-cell parameters a=b=58.02, c=71.11 A, alpha=beta=90, gamma=120 degrees. PMID: 20693673
    6. Human keratinocytes were transfected with either Flip, Faim, or Lifeguard (LFG). Our results suggest that heterotopic expression of antiapoptotic proteins can induce the resistance of keratinocytes to a major mechanism of rejection. PMID: 17912957
    7. Expression of the long form of Fas apoptotic inhibitory molecule (FAIML) results in the protection of neurons from the cytotoxic actions of death ligands. PMID: 17942717
    8. FAIM acts to specifically enhance CD40 signaling for NF-kappaB activation, IRF-4 expression, and BCL-6 down-regulation in vitro, but has no effect on its own PMID: 19592656

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    FAIM1 family
  • 数据库链接：

    HGNC: 18703

    OMIM: 617535

    KEGG: hsa:55179

    STRING: 9606.ENSP00000342805

    UniGene: Hs.173438