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  4. Recombinant Human Fez family zinc finger protein 2 (FEZF2)

Recombinant Human Fez family zinc finger protein 2 (FEZF2)

  • 中文名称：
    人FEZF2重组蛋白
  • 货号：
    CSB-YP851534HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人FEZF2重组蛋白
  • 货号：
    CSB-EP851534HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人FEZF2重组蛋白
  • 货号：
    CSB-EP851534HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人FEZF2重组蛋白
  • 货号：
    CSB-BP851534HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人FEZF2重组蛋白
  • 货号：
    CSB-MP851534HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    FEZF2
  • Uniprot No.：
  • 别名：
    FEZF2; FEZL; ZNF312; FKSG36Fez family zinc finger protein 2; Forebrain embryonic zinc finger-like protein 2; Zinc finger protein 312; Zinc finger protein Fez-like
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-459
  • 氨基酸序列
    MASSASLETM VPPACPRAGA SPATSKTLAF SIERIMAKTS EPRAPFEPRP GALEADGSQG KKLLNLCSPL PCMIPLQPLG YEVPSKTLLS YSELWKSSLR AGGGGGGGGG GGGGGGGAPV CGASGLCKTN CGVCCKAELG LAPSALPAGR VIKPQVINQA VGLPASGSLY YFNYLDSTAY PPSELLSGHL FPSGLLNAQA PAALAAHPKL FLLENAKLAG LAADKFPHPA PYPHKERLPA PLEQVLKENS ALTAERGGVK GHSKLPGGSA DGKPKNFTCE VCGKVFNAHY NLTRHMPVHT GARPFVCKVC GKGFRQASTL CRHKIIHTQE KPHKCNQCGK AFNRSSTLNT HIRIHAGYKP FVCEFCGKGF HQKGNYKNHK LTHSGEKQYK CTICNKAFHQ VYNLTFHMHT HNDKKPFTCA TCGKGFCRNF DLKKHVRKLH DSVGPAAPSA KDLTRTVQS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription repressor. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons. May be involved in innate immunity.
  • 基因功能参考文献：
    1. Fezf1 and Fezf2 accomplish both independent and redundant functions across diverse tissue and cell types. [Review] PMID: 24913420
    2. FEZF2 expression has a role in cell proliferation and differentiation in adult neural stem cells. PMID: 25319688
    3. This study reports the differentiation of a hFezf2-YFP human embryonic stem cell reporter line into corticofugal projection neurons. PMID: 23826257
    4. overexpression of EZH2 was frequently detected in NPC tumors. Thus, we have identified FEZF2 as a novel 3p14.2 TSG frequently inactivated by promoter methylation in NPC, which functions as a repressor downregulating multiple oncogene expression PMID: 23677067
    5. the feasibility of employing genomic SELEX to identify vertebrate transcription factor binding sites and target genes and reveal Fezf2 as a transcription activator and a candidate for evaluation in human microcephaly. PMID: 21471212
    6. ZNF312 and other brain-layer biomarkers have area dependent expressions in the human fetal cortex. PMID: 20570630

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Krueppel C2H2-type zinc-finger protein family
  • 数据库链接：

    HGNC: 13506

    OMIM: 607414

    KEGG: hsa:55079

    STRING: 9606.ENSP00000283268

    UniGene: Hs.241523