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  4. Recombinant Human Forkhead box protein P4 (FOXP4)

Recombinant Human Forkhead box protein P4 (FOXP4)

  • 货号：
    CSB-YP812873HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP812873HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP812873HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP812873HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP812873HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    FOXP4
  • Uniprot No.：
  • 别名：
    1200010K03Rik; 2310007G05Rik; FKHLA; FLJ40908; FLJ44184; Fork head related protein like A; Fork head-related protein-like A; Forkhead box P4; Forkhead box protein P4; FOX P4; FOXP 4; foxp4; FOXP4_HUMAN; hFKHLA; mFKHLA; OTTHUMP00000016374; OTTHUMP00000039784; OTTHUMP00000043412; OTTHUMP00000043536; Winged helix repressor FOX P4; Winged helix repressor FOXP 4; Winged helix repressor FOXP4
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-680
  • 氨基酸序列
    MMVESASETI RSAPSGQNGV GSLSGQADGS SGGATGTTAS GTGREVTTGA DSNGEMSPAE LLHFQQQQAL QVARQFLLQQ ASGLSSPGNN DSKQSASAVQ VPVSVAMMSP QMLTPQQMQQ ILSPPQLQAL LQQQQALMLQ QLQEYYKKQQ EQLHLQLLTQ QQAGKPQPKE ALGNKQLAFQ QQLLQMQQLQ QQHLLNLQRQ GLVSLQPNQA SGPLQTLPQA AVCPTDLPQL WKGEGAPGQP AEDSVKQEGL DLTGTAATAT SFAAPPKVSP PLSHHTLPNG QPTVLTSRRD SSSHEETPGS HPLYGHGECK WPGCETLCED LGQFIKHLNT EHALDDRSTA QCRVQMQVVQ QLEIQLAKES ERLQAMMAHL HMRPSEPKPF SQPLNPVPGS SSFSKVTVSA ADSFPDGLVH PPTSAAAPVT PLRPPGLGSA SLHGGGPARR RSSDKFCSPI SSELAQNHEF YKNADVRPPF TYASLIRQAI LETPDRQLTL NEIYNWFTRM FAYFRRNTAT WKNAVRHNLS LHKCFVRVEN VKGAVWTVDE REYQKRRPPK MTGSPTLVKN MISGLSYGAL NASYQAALAE SSFPLLNSPG MLNPGSASSL LPLSHDDVGA PVEPLPSNGS SSPPRLSPPQ YSHQVQVKEE PAEAEEDRQP GPPLGAPNPS ASGPPEDRDL EEELPGEELS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional repressor that represses lung-specific expression.
  • 基因功能参考文献：
    1. results indicated lncRNA MFI2 could promote proliferation and migration of osteosarcoma cells by regulating FOXP4 expression, which suggested critical roles of lncRNA MFI2 and FOXP4 in occurrence and development of human osteosarcoma PMID: 27513470
    2. FOXP4 and SHROOM1 genes are hypermethylated in the knee osteoarthritic cartilage. PMID: 26484395
    3. High FOXP4 expression is associated with non-small cell lung cancer. PMID: 25994569
    4. rs4714476 at the 5' near gene of FOXP4 potentially contributes to the susceptibility of prostate cancer in Chinese men PMID: 26642711
    5. These findings suggest that miR-338-3p regulates survival of hepatocellular carcinoma cells partially through the downregulation of FOXP4 PMID: 25755720
    6. Foxp4 is dispensable for T cell development, but necessary for normal T cell cytokine recall responses to antigen following pathogenic infection PMID: 22912696
    7. these data implicate specific members of the FOX family of TFs (FOXC1, C2, P1, P4, and O1A) not previously suggested in heart failure pathogenesis. PMID: 16952980
    8. Contrary to the current view, T cell receptor-mediated signals are not responsible for the induction of FOXP3 in human thymocytes. PMID: 18322169

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 20842

    OMIM: 608924

    KEGG: hsa:116113

    STRING: 9606.ENSP00000309823

    UniGene: Hs.131436