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  4. Recombinant Human Gamma-aminobutyric acid receptor subunit pi (GABRP), partial

Recombinant Human Gamma-aminobutyric acid receptor subunit pi (GABRP), partial

  • 中文名称：
    人GABRP重组蛋白
  • 货号：
    CSB-YP009154HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人GABRP重组蛋白
  • 货号：
    CSB-EP009154HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人GABRP重组蛋白
  • 货号：
    CSB-BP009154HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人GABRP重组蛋白
  • 货号：
    CSB-MP009154HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    GABRP
  • Uniprot No.：
  • 别名：
    GABA(A) receptor subunit pi; GABRP; Gamma aminobutyric acid (GABA) A receptor pi; Gamma aminobutyric acid A receptor pi; Gamma aminobutyric acid receptor pi subunit; Gamma aminobutyric acid receptor subunit pi; Gamma-aminobutyric acid receptor subunit pi; GBRP_HUMAN; MGC126386; MGC126387
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function of the receptor appears to be related to tissue contractility. The binding of this pI subunit with other GABA(A) receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone.
  • 基因功能参考文献：
    1. rs505474, rs1398175, and rs4868029 in the GABRA2, GABRA4, and GABRP genes, respectively, allele frequencies were significantly different between patients and controls.Four haplotypes were significantly associated with Bipolar Disorder (TA and AG for rs3815762 and rs4868029 in GABRP, GG for rs11636988 and rs8024256 in GABRB3 and GAGG for rs2197414, rs4921195, rs13188991, and rs11956731 in GABRA6. PMID: 29135068
    2. Hypomethylation of the GABRP promoter is associated with aggressive phenotype of ovarian cancer. PMID: 28524180
    3. genetic polymorphism is associated with systemic lupus erythematosus in female patients PMID: 26634217
    4. data reveal a GABRP-ERK1/2-cytokeratin axis that maintains the migratory phenotype of basal-like breast cancer PMID: 25012653
    5. HOXA10 expression leads to production of a less progestin-responsive GABA receptor subtype pi PMID: 20103740
    6. Data suggest that GABRP is progressively down-regulated with tumour-progression, and that it may be useful as a prognostic marker in breast cancer. PMID: 16187283

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  • 亚细胞定位：
    Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Ligand-gated ion channel (TC 1.A.9) family, Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily, GABRP sub-subfamily
  • 组织特异性：
    Most abundant in the uterus, also expressed in lung, thymus and prostate.
  • 数据库链接：

    HGNC: 4089

    OMIM: 602729

    KEGG: hsa:2568

    STRING: 9606.ENSP00000265294

    UniGene: Hs.26225