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  4. Recombinant Human Glutamate decarboxylase-like protein 1 (GADL1)

Recombinant Human Glutamate decarboxylase-like protein 1 (GADL1)

  • 中文名称：
    人GADL1重组蛋白
  • 货号：
    CSB-YP744410HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人GADL1重组蛋白
  • 货号：
    CSB-EP744410HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人GADL1重组蛋白
  • 货号：
    CSB-EP744410HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人GADL1重组蛋白
  • 货号：
    CSB-BP744410HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人GADL1重组蛋白
  • 货号：
    CSB-MP744410HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    GADL1
  • Uniprot No.：
  • 别名：
    GADL1Acidic amino acid decarboxylase GADL1; Aspartate 1-decarboxylase; ADC; HuADC; EC 4.1.1.11; Cysteine sulfinic acid decarboxylase; CSADC; HuCSADC; EC 4.1.1.29; Glutamate decarboxylase-like protein 1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-521
  • 氨基酸序列
    MSSDSDRQCP VDGDIDQQEM IPSKKNAVLV DGVVLNGPTT DAKAGEKFVE EACRLIMEEV VLKATDVNEK VCEWRPPEQL KQLLDLEMRD SGEPPHKLLE LCRDVIHYSV KTNHPRFFNQ LYAGLDYYSL VARFMTEALN PSVYTYEVSP VFLLVEEAVL KKMIEFIGWK EGDGIFNPGG SVSNMYAMNL ARYKYCPDIK EKGLSGSPRL ILFTSAECHY SMKKAASFLG IGTENVCFVE TDGRGKMIPE ELEKQVWQAR KEGAAPFLVC ATSGTTVLGA FDPLDEIADI CERHSLWLHV DASWGGSALM SRKHRKLLHG IHRADSVAWN PHKMLMAGIQ CCALLVKDKS DLLKKCYSAK ASYLFQQDKF YDVSYDTGDK SIQCSRRPDA FKFWMTWKAL GTLGLEERVN RALALSRYLV DEIKKREGFK LLMEPEYANI CFWYIPPSLR EMEEGPEFWA KLNLVAPAIK ERMMKKGSLM LGYQPHRGKV NFFRQVVISP QVSREDMDFL LDEIDLLGKD M
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May catalyze the decarboxylation of L-aspartate, 3-sulfino-L-alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. Does not exhibit any decarboxylation activity toward glutamate.
  • 基因功能参考文献：
    1. No difference in GADL1 expression was observed among lymphoblastoid cells from excellent-responders, non-responders or controls. Furthermore, lithium did not induce significant changes in GADL1 expression levels after 4 or 8 days. These results did not support an association of GADL1 expression in the determination of a lithium response in BD patients. PMID: 28214779
    2. taurine biosynthesis in vertebrates involves two structurally related PLP-dependent decarboxylases (cysteine sulfinic acid decarboxylase and glutamic acid decarboxylase like 1) PMID: 26327310
    3. The study did not identify a major relationship between the GADL1 polymorphisms and lithium response in an Indian population. PMID: 25415457
    4. Genetic variations in GADL1 are associated with the response to lithium maintenance treatment for bipolar I disorder in patients of Han Chinese descent. PMID: 24369049
  • 蛋白家族：
    Group II decarboxylase family
  • 组织特异性：
    Expressed very weakly in neurons and not detected in astrocytes, brain or liver.
  • 数据库链接：

    HGNC: 27949

    OMIM: 615601

    KEGG: hsa:339896

    STRING: 9606.ENSP00000282538

    UniGene: Hs.657052