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  4. Recombinant Human Glycoprotein hormone beta-5 (GPHB5)

Recombinant Human Glycoprotein hormone beta-5 (GPHB5)

  • 中文名称：
    人GPHB5重组蛋白
  • 货号：
    CSB-YP774839HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人GPHB5重组蛋白
  • 货号：
    CSB-EP774839HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人GPHB5重组蛋白
  • 货号：
    CSB-EP774839HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人GPHB5重组蛋白
  • 货号：
    CSB-BP774839HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人GPHB5重组蛋白
  • 货号：
    CSB-MP774839HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    GPHB5
  • Uniprot No.：
  • 别名：
    GPHB5; GPB5; ZLUT1Glycoprotein hormone beta-5; Thyrostimulin subunit beta
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    25-130
  • 氨基酸序列
    ASSGNL RTFVGCAVRE FTFLAKKPGC RGLRITTDAC WGRCETWEKP ILEPPYIEAH HRVCTYNETK QVTVKLPNCA PGVDPFYTYP VAIRCDCGAC STATTECETI
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Functions as a heterodimeric glycoprotein hormone with GPHA2 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism.
  • 基因功能参考文献：
    1. Thyrostimulin, a heterodimer of two new human glycoprotein hormone subunits, activates the thyroid-stimulating hormone receptor (thyrostimulin) PMID: 12045258
    2. identification and characterization of GPB5 genes PMID: 12089349
    3. Srosophila GPA2/GPB5 heterodimers did not activate human TSH or gonadotropin receptors, chimeric fly GPA2/human GPB5 heterodimers stimulated human TSH receptors. (GPA2 in drosophila) PMID: 15890769
    4. Dual site-disrupted GPA2 and the GPB5 mutant were not expressed in either the conditioned medium or cell lysate. PMID: 18433898
    5. Inflammatory cytokines positively regulate thyrostimulin through NF-kappaB activation. PMID: 19095738

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Glycoprotein hormones subunit beta family
  • 组织特异性：
    Highly expressed in brain and at low levels in pituitary. Also found in retina, testis and skin but not in pancreas, parotid, kidney, stomach, liver, colon, small intestine, thyroid, brain or adrenal gland. In pituitary, colocalizes with ACTH, suggesting
  • 数据库链接：

    HGNC: 18055

    OMIM: 609652

    KEGG: hsa:122876

    UniGene: Hs.375028