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  4. Recombinant Human High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor (FCAMR), partial

Recombinant Human High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor (FCAMR), partial

  • 中文名称：
    人FCAMR重组蛋白
  • 货号：
    CSB-YP823899HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人FCAMR重组蛋白
  • 货号：
    CSB-EP823899HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人FCAMR重组蛋白
  • 货号：
    CSB-EP823899HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人FCAMR重组蛋白
  • 货号：
    CSB-BP823899HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人FCAMR重组蛋白
  • 货号：
    CSB-MP823899HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    CD351; Fc alpha/mu receptor; Fc receptor, IgA, IgM, high affinity; Fcamr; FCAMR_HUMAN; FKSG87; High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor; Immunity related factor; Receptor for Fc fragment of IgA and IgM
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Functions as a receptor for the Fc fragment of IgA and IgM. Binds IgA and IgM with high affinity and mediates their endocytosis. May function in the immune response to microbes mediated by IgA and IgM.
  • 基因功能参考文献：
    1. A genome-wide trans-ethnic interaction study links the PIGR-FCAMR locus to coronary atherosclerosis via interactions between genetic variants and residential exposure to traffic pollution. PMID: 28355232
    2. rs3125923 FCAMR gene represents a validated SNP to predict grade 3-4 Taxane-induced peripheral neuropathy . Genetically determined AA race represents the most significant predictor of TIPN. PMID: 26138065
    3. A significantly worse survival was found in patients with IgA serum levels>2.85 g/l compared to patients with lower IgA serum levels. PMID: 25845491
    4. ADAM10 and ADAM17 are involved in the shedding of FcalphaR PMID: 20059578
    5. LPS, through the TLR4 receptor, activates the p38MAPK and NF-kappaB pathways and up-regulate the expression of Fcamr in human macrophages PMID: 19682689
    6. These results suggest that the cytoplasmic portion is required for the dimer formation and thus for efficient cell surface expression of Fcalpha/microR. PMID: 19945166
    7. Comprehensive survey of naturally occurring polymorphisms in rhesus macaques and in humans. PMID: 18379868
    8. These results indicate for the first time that Fcalpha/muR protein is expressed by human intestinal tissues PMID: 19338768
    9. the cytoplasmic portion of human Fcalpha/microR is required in the internalization. PMID: 19393604

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Expressed by mesangial cells.
  • 数据库链接：

    HGNC: 24692

    OMIM: 605484

    KEGG: hsa:83953

    STRING: 9606.ENSP00000316491

    UniGene: Hs.145519