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  4. Recombinant Human Homeobox protein aristaless-like 4 (ALX4)

Recombinant Human Homeobox protein aristaless-like 4 (ALX4)

  • 中文名称：
    Recombinant Human Homeobox protein aristaless-like 4(ALX4),Yeast
  • 货号：
    CSB-YP884437HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Homeobox protein aristaless-like 4(ALX4),Yeast
  • 货号：
    CSB-EP884437HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Homeobox protein aristaless-like 4(ALX4),Yeast
  • 货号：
    CSB-EP884437HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Homeobox protein aristaless-like 4(ALX4),Yeast
  • 货号：
    CSB-BP884437HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Homeobox protein aristaless-like 4(ALX4),Yeast
  • 货号：
    CSB-MP884437HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ALX4
  • Uniprot No.：
  • 别名：
    Alx4; ALX4_HUMAN; Aristaless like homeobox 4; CRS5; FND2; FPP; homeobox protein aristaless like 4; Homeobox protein aristaless-like 4; homeodomain transcription factor ALX4; KIAA1788; PFM1; PFM2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-411
  • 氨基酸序列
    MNAETCVSYC ESPAAAMDAY YSPVSQSREG SSPFRAFPGG DKFGTTFLSA AAKAQGFGDA KSRARYGAGQ QDLATPLESG AGARGSFNKF QPQPSTPQPQ PPPQPQPQQQ QPQPQPPAQP HLYLQRGACK TPPDGSLKLQ EGSSGHSAAL QVPCYAKESS LGEPELPPDS DTVGMDSSYL SVKEAGVKGP QDRASSDLPS PLEKADSESN KGKKRRNRTT FTSYQLEELE KVFQKTHYPD VYAREQLAMR TDLTEARVQV WFQNRRAKWR KRERFGQMQQ VRTHFSTAYE LPLLTRAENY AQIQNPSWLG NNGAASPVPA CVVPCDPVPA CMSPHAHPPG SGASSVTDFL SVSGAGSHVG QTHMGSLFGA ASLSPGLNGY ELNGEPDRKT SSIAALRMKA KEHSAAISWA T
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor involved in skull and limb development. Plays an essential role in craniofacial development, skin and hair follicle development.
  • 基因功能参考文献：
    1. We reveal for the first time that ALX4 acts as a novel functional tumor suppressor inactivated by DNA methylation and is an independent prognostic factor in breast cancer PMID: 29183346
    2. overexpression of ALX4 inhibited the proliferation, invasion, and epithelial-mesenchymal transition (EMT) in HCC cells. ALX4 had an inhibitory effect on the sonic hedgehog (Shh) signaling pathway. PMID: 28081728
    3. mother of Case 2 also had a mutation in the ALX4 gene, but no enlarged parietal foramina PMID: 27349084
    4. Our results show that HOXB13/SLUG and ALX4/SLUG axes are novel pathways that promote EMT and invasion of ovarian cancer cells. PMID: 25944620
    5. High-quality solution NMR structures of three homeodomains from human proteins ALX4, ZHX1 and CASP8AP2 were solved. PMID: 24941917
    6. We suggest that all ALX4 heterozygote carriers be examined in detail for possible changes in nasal configuration, to establish a detailed genotype-phenotype correlation, leading the way to more comprehensive genetic counseling. PMID: 24764194
    7. Epigenetic silencing of Aristaless-like homeobox-4 is associated with lung cancer. PMID: 24037716
    8. study describes 2 related individuals with a heterozygous mutation in ALX4 presenting a distinct phenotype of frontonasal dysplasia; suggest that the loss of the ALX4 OAR domain with the maintenance of the homeodomain impairs the function of the normal allele in a dominant-negative effect PMID: 23401352
    9. ALX4 variants may have an impact on the genetic etiology of nonsyndromic craniosynostosis. PMID: 22829454
    10. Exclusion of mutations in ALX4 gene in patients with the syndrome of frontonasal dysgenesis, callosal agenesis, basal encephalocele, and eye anomalies PMID: 22496059
    11. Downregulation of HoxB2, HoxB4 and Alx4 expression during the narrow window of early embryogenesis may cause omphalocele in the Cd chick model by interfering with molecular signaling required for proper VBW formation. PMID: 20625746
    12. Data show that methylated DNA from advanced precancerous colorectal lesions can be detected using a panel of two DNA methylation markers, ALX4 and SEPT9. PMID: 20140221
    13. data show a distinct pattern of expression of ALX4 in the human breast relative to the murine mammary gland, and the loss of ALX4 in tumours and the surrounding untransformed stroma is a basic characteristic of ductal carcinoma. PMID: 19783719
    14. ALX4 plays a critical role in craniofacial and epidermal development. PMID: 19692347
    15. One subject with parietal foramina whose deletion does not include ALX4 indicates that ALX4 in this subject may be rendered functionally haploinsufficient by a position effect. PMID: 15852040
    16. The ALX4 mutation p.R218Q tends to result in persistent cranium bifidum and is associated with anatomical abnormalities of the posterior fossa. PMID: 16319823

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  • 相关疾病：
    Parietal foramina 2 (PFM2); Frontonasal dysplasia 2 (FND2); Potocki-Shaffer syndrome (POSHS); Craniosynostosis 5 (CRS5)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Paired homeobox family
  • 组织特异性：
    Expression is likely to be restricted to bone. Found in parietal bone.
  • 数据库链接：

    HGNC: 450

    OMIM: 601224

    KEGG: hsa:60529

    STRING: 9606.ENSP00000332744

    UniGene: Hs.436055