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  4. Recombinant Human Importin subunit alpha-8 (KPNA7)

Recombinant Human Importin subunit alpha-8 (KPNA7)

  • 中文名称：
    人KPNA7重组蛋白
  • 货号：
    CSB-YP012489HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人KPNA7重组蛋白
  • 货号：
    CSB-EP012489HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人KPNA7重组蛋白
  • 货号：
    CSB-EP012489HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人KPNA7重组蛋白
  • 货号：
    CSB-BP012489HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人KPNA7重组蛋白
  • 货号：
    CSB-MP012489HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    KPNA7
  • Uniprot No.：
  • 别名：
    KPNA7; Importin subunit alpha-8; Karyopherin subunit alpha-7
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-516
  • 氨基酸序列
    MPTLDAPEER RRKFKYRGKD VSLRRQQRMA VSLELRKAKK DEQTLKRRNI TSFCPDTPSE KTAKGVAVSL TLGEIIKGVN SSDPVLCFQA TQTARKMLSQ EKNPPLKLVI EAGLIPRMVE FLKSSLYPCL QFEAAWALTN IASGTSEQTR AVVEGGAIQP LIELLSSSNV AVCEQAVWAL GNIAGDGPEF RDNVITSNAI PHLLALISPT LPITFLRNIT WTLSNLCRNK NPYPCDTAVK QILPALLHLL QHQDSEVLSD ACWALSYLTD GSNKRIGQVV NTGVLPRLVV LMTSSELNVL TPSLRTVGNI VTGTDEQTQM AIDAGMLNVL PQLLQHNKPS IQKEAAWALS NVAAGPCHHI QQLLAYDVLP PLVALLKNGE FKVQKEAVWM VANFATGATM DQLIQLVHSG VLEPLVNLLT APDVKIVLII LDVISCILQA AEKRSEKENL CLLIEELGGI DRIEALQLHE NRQIGQSALN IIEKHFGEEE DESQTLLSQV IDQDYEFIDY ECLAKK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Functions in nuclear protein import.
  • 基因功能参考文献：
    1. KPNA7 has a critical role in the regulation of mitosis through the proper organization of the mitotic spindle and acts in the maintenance of the nuclear envelope structure and nuclear morphology. PMID: 29580221
    2. KPNA7 binding and nuclear transfer was validated for two proteins, MVP and ZNF414. MVP and ZNF414 have a key role in the regulation of pancreatic cancer cell growth. PMID: 27664836
    3. Our data show that compound heterozygous mutations in KPNA7 are associated with a human neurodevelopmental disease, and provide the first example of a human disease associated with mutation of a nuclear transport receptor. PMID: 24045845
    4. Bel1 fragment with residues 215-223, which bears the NLS, interacts with KPNA1, KPNA6, and KPNA7. PMID: 25272585
    5. KPNA7 silencing inhibits the malignant properties of pancreatic cancer cells in vitro and thereby provide the first evidence on the functional role for KPNA7 in human cancer. PMID: 24275456

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Importin alpha family
  • 数据库链接：

    HGNC: 21839

    OMIM: 614107

    KEGG: hsa:402569

    STRING: 9606.ENSP00000330878

    UniGene: Hs.253050