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  4. Recombinant Human LYR motif-containing protein 1 (LYRM1)

Recombinant Human LYR motif-containing protein 1 (LYRM1)

  • 货号：
    CSB-YP013272HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP013272HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP013272HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP013272HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP013272HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    LYRM1
  • Uniprot No.：
  • 别名：
    1110065L10Rik; 2310004B22Rik; 4930404J24Rik; A211C6.1; LYR motif containing 1; LYR motif containing protein 1; LYR motif-containing protein 1; LYRM 1; lyrm1; LYRM1_HUMAN; OTTHUMP00000162292; OTTMUSP00000031126; OTTMUSP00000031127; OTTMUSP00000031128; OTTMUSP00000031129; RGD1563498
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-122
  • 氨基酸序列
    MTTATRQEVL GLYRSIFRLA RKWQATSGQM EDTIKEKQYI LNEARTLFRK NKNLTDTDLI KQCIDECTAR IEIGLHYKIP YPRPIHLPPM GLTPLRGRGL RSQEKLRKLS KPVYLRSHDE VS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May promote cell proliferation and inhibition of apoptosis of preadipocytes.
  • 基因功能参考文献：
    1. alpha-LA protects 3T3-L1 adipocytes from LYRM1-induced insulin resistance partially via its capacity to restore mitochondrial function and/or increase phosphorylation of IRS-1 and Akt. PMID: 22820890
    2. overexpression of LYRM1 caused mitochondrial dysfunction in adipocytes, which might be responsible for the development of LYRM1-induced insulin resistance PMID: 20826099
    3. Data suggest that LYRM1 might have the potential to modulate cell growth, apoptosis, and heart development. PMID: 20938407
    4. By increasing cell proliferation and lowering the rate of apoptosis, LYRM1 has the potential to modulate the size of the preadipocyte pool and influence adipose tissue homeostasis PMID: 19022914
  • 相关疾病：
    When overexpressed, may be involved in obesity-associated insulin resistance, possibly by causing mitochondrial dysfunction in adipocytes.
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Complex I LYR family
  • 组织特异性：
    High levels in adipose tissue.
  • 数据库链接：

    HGNC: 25074

    OMIM: 614709

    KEGG: hsa:57149

    STRING: 9606.ENSP00000219168

    UniGene: Hs.745012