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  4. Recombinant Human Matrix metalloproteinase-26 (MMP26)

Recombinant Human Matrix metalloproteinase-26 (MMP26)

  • 中文名称：
    人MMP26重组蛋白
  • 货号：
    CSB-YP889091HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人MMP26重组蛋白
  • 货号：
    CSB-EP889091HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人MMP26重组蛋白
  • 货号：
    CSB-EP889091HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人MMP26重组蛋白
  • 货号：
    CSB-BP889091HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人MMP26重组蛋白
  • 货号：
    CSB-MP889091HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    MMP26
  • Uniprot No.：
  • 别名：
    MMP26; Matrix metalloproteinase-26; MMP-26; EC 3.4.24.-; Endometase; Matrilysin-2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    90-261
  • 氨基酸序列
    T SISPGRCKWN KHTLTYRIIN YPHDMKPSAV KDSIYNAVSI WSNVTPLIFQ QVQNGDADIK VSFWQWAHED GWPFDGPGGI LGHAFLPNSG NPGVVHFDKN EHWSASDTGY NLFLVATHEI GHSLGLQHSG NQSSIMYPTY WYHDPRTFQL SADDIQRIQH LYGEKCSSDI P
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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靶点详情

  • 功能：
    May hydrolyze collagen type IV, fibronectin, fibrinogen, beta-casein, type I gelatin and alpha-1 proteinase inhibitor. Is also able to activate progelatinase B.
  • 基因功能参考文献：
    1. MMP26 is overexpressed in prostatic neoplasms patients, and can serve as a serum disease biomarker. PMID: 29270749
    2. The luciferase report assay demonstrated that MMP26 is a target gene of miR-125b. And the expression profile of MMP26 showed an inverse relationship with miR-125b in vivo and in vitro. PMID: 27143441
    3. MMP26+CXCR4+ cells may be circulating tumor cells in hepatocellular carcinoma. PMID: 26279442
    4. We found that only inhibition of JNK significantly decreased the activation of MMP26 in response to FGF1 stimulation, suggesting that activation of FGFR1 signaling may activate JNK to activate MMP26 in non-small-cell lung cancer PMID: 25566961
    5. Overexpression of MMP26 in SW1353 cells increased cell invasiveness, while inhibition of MMP26 decreased cell invasiveness. PMID: 25262277
    6. The binding of MMP-26 to GDF15 was responsible for the processing and maturation of pro-GDF15, and the process was dependent on enzymatic activity of MMP-26. In human placental trophoblast cells, MMP-26 could facilitate the pro-apoptotic effect of GDF15. PMID: 25093616
    7. matrilysin-2 was an independent prognostic marker for patients with colorectal cancer PMID: 24318970
    8. These results demonstrate that the HOXA10-mediated expression of MMP-26 promotes embryo adhesion during the process of embryonic implantation. PMID: 24565841
    9. The MMP-26 promoter region contains a putative ER response element. PMID: 23754174
    10. expression of MMP-26 protein was predominantly located in pre- and early-invasive areas suggesting MMP-26 expression as an early event in promoting GM-CSF dependent tumor invasion. PMID: 23634280
    11. Molecular analyses showed significant downregulation of expression of MMP-26 (p=0.03), and significant 9.8-fold upregulation of TGF-beta (p=0.01) in more degenerated discs vs. healthier discs. PMID: 21945733
    12. MMP-26 plays an important role in local invasion at least in part through coordination with MMP-9. PMID: 21805034
    13. direct association observed between morphological scores of malignancy and MMP immunoreactivity, with the association being significant for MMP-26. present results demonstrate important role of MMPs in development of SCCs of lower lip and tongue. PMID: 21255765
    14. MMP-26 expression may be associated with multiple human carcinomas. MMP-26 may also contribute to smooth muscle function in the human prostate and cardiovascular system. PMID: 19895737
    15. role of these proteins in the process of invasion and metastasis cannot be ruled out since their presence is more marked along the tumor invasion front compared to more central areas of squamous cell carcinoma of the tongue PMID: 20491537
    16. GnRH I and II could up-regulate MMP-26 expression through the JNK signaling pathway in human trophoblast-like/trophoblast cells. PMID: 20074375
    17. MMP-26 contributes to tumor cell invasion, migration and angiogenesis PMID: 19956866
    18. MMP-26 expression in stroma is associated with larger Merkel cell carcinoma with poor prognosis. PMID: 19921252
    19. can cleave all subclasses of igG at a specific conserved site PMID: 11841844
    20. role of histidine(81) in mechanism of activation PMID: 11889136
    21. Promoter characterization of the novel human matrix metalloproteinase-26 gene: regulation by the T-cell factor-4 implies specific expression of the gene in cancer cells of epithelial origin. PMID: 11931652
    22. substrate specificity and protein cleavage sites PMID: 12119297
    23. Details of cleavage of pro-MMP-9 by MMP-26, facilitating the efficient cleavage of fibronectin by MMP-9, and promoting invasiveness of ARCaP cells across fibronectin or type IV collagen PMID: 12586837
    24. Present throughout menstrual cycle. Elevated during early to mid-luteal phase. Elevations in users of levonorgestrel implants experiencing irregular uterine bleeding. Seems to play role in hormonal regulation and endometrial tissue remodeling. PMID: 12969699
    25. distinguish shallow, intermediate, and deep S1' pocket characteristics PMID: 14532275
    26. MMP-26 was colocalized with MMP-9, TIMP-2, and TIMP-4 in breast cancer cells. PMID: 14744773
    27. Results suggest a functional relationship between TIMP-4 mRNA and MMP-26 mRNA, and possibly a role in human implantation. PMID: 15273280
    28. Matrilysin-2 overexpression is associated with tumor progression and activation of MMP-9 in esophageal squamous cell carcinoma PMID: 15333466
    29. The expression patterns of MMP26 in human placenta suggests complicated roles for MMP26 during the processes of placentation and hematopoiesis PMID: 15601912
    30. During esophageal tumorigenesis, MMP-21 and MMP-26 have different, unique expression patterns. PMID: 16641547
    31. Maximal expression of MMP-26, in the early and mid-secretory phase suggests its role during implantation and results show it is stored in epithelial cells, is not released spontaneously, and is controlled by TIMP-4 in both stroma and uterine fluid. PMID: 16809379
    32. Results indicate that MMP-26 and TIMP-4 may play an integral role during the conversion of high-grade prostatic intraepithelial neoplasia to invasive cancer and may also serve as markers for early prostate cancer diagnosis. PMID: 16940965
    33. results suggest that MMP-21 and MMP-26 are not only associated with cancer but may be important in connective tissue remodelling and pathobiology of various benign skin disorde PMID: 16984259
    34. A human breast cancer cell linetransfected with wild-type MMP-26 cDNA showed a calcium-dependent invasive potential when compared with controls. PMID: 17176253
    35. The putative role of MMP-26 as a marker of metastasesin pancreatic cancer warrants further studies PMID: 17873896
    36. expression of transmembrane 4 superfamily member 4 (TM4SF4) and matrix metalloproteinase 26 (MMP26) was found to be significantly decreased during the implantation window in patients with polycystic ovary syndrome. PMID: 18765015
    37. MMP-26 may be served as a tumor marker in monitoring progression and predicting prognosis of non-small cell lung cancer. PMID: 19448419
    38. MMP-26 and MMP-9 may contribute to the more aggressive behavior of squamous cell carcinomas in organ transplant recipients PMID: 19674198

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  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Peptidase M10A family
  • 组织特异性：
    Expressed specifically in uterus and placenta. Is also widely expressed in malignant tumors from different sources as well as in diverse tumor cell lines.
  • 数据库链接：

    HGNC: 14249

    OMIM: 605470

    KEGG: hsa:56547

    STRING: 9606.ENSP00000300762

    UniGene: Hs.204732