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  4. MMP26 Antibody

MMP26 Antibody

  • 中文名称：
    MMP26兔多克隆抗体
  • 货号：
    CSB-PA283929
  • 规格：
    ￥1100
  • 图片：
    • Gel: 10%SDS-PAGE, Lysate: 60 μg, Lane: 293T cells, Primary antibody: CSB-PA283929(MMP26 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 minutes
  • 其他：

产品详情

  • Uniprot No.：
    Q9NRE1
  • 基因名：
    MMP26
  • 别名：
    MMP26 antibody; Matrix metalloproteinase-26 antibody; MMP-26 antibody; EC 3.4.24.- antibody; Endometase antibody; Matrilysin-2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human MMP26
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May hydrolyze collagen type IV, fibronectin, fibrinogen, beta-casein, type I gelatin and alpha-1 proteinase inhibitor. Is also able to activate progelatinase B.
  • 基因功能参考文献：
    1. MMP26 is overexpressed in prostatic neoplasms patients, and can serve as a serum disease biomarker. PMID: 29270749
    2. The luciferase report assay demonstrated that MMP26 is a target gene of miR-125b. And the expression profile of MMP26 showed an inverse relationship with miR-125b in vivo and in vitro. PMID: 27143441
    3. MMP26+CXCR4+ cells may be circulating tumor cells in hepatocellular carcinoma. PMID: 26279442
    4. We found that only inhibition of JNK significantly decreased the activation of MMP26 in response to FGF1 stimulation, suggesting that activation of FGFR1 signaling may activate JNK to activate MMP26 in non-small-cell lung cancer PMID: 25566961
    5. Overexpression of MMP26 in SW1353 cells increased cell invasiveness, while inhibition of MMP26 decreased cell invasiveness. PMID: 25262277
    6. The binding of MMP-26 to GDF15 was responsible for the processing and maturation of pro-GDF15, and the process was dependent on enzymatic activity of MMP-26. In human placental trophoblast cells, MMP-26 could facilitate the pro-apoptotic effect of GDF15. PMID: 25093616
    7. matrilysin-2 was an independent prognostic marker for patients with colorectal cancer PMID: 24318970
    8. These results demonstrate that the HOXA10-mediated expression of MMP-26 promotes embryo adhesion during the process of embryonic implantation. PMID: 24565841
    9. The MMP-26 promoter region contains a putative ER response element. PMID: 23754174
    10. expression of MMP-26 protein was predominantly located in pre- and early-invasive areas suggesting MMP-26 expression as an early event in promoting GM-CSF dependent tumor invasion. PMID: 23634280
    11. Molecular analyses showed significant downregulation of expression of MMP-26 (p=0.03), and significant 9.8-fold upregulation of TGF-beta (p=0.01) in more degenerated discs vs. healthier discs. PMID: 21945733
    12. MMP-26 plays an important role in local invasion at least in part through coordination with MMP-9. PMID: 21805034
    13. direct association observed between morphological scores of malignancy and MMP immunoreactivity, with the association being significant for MMP-26. present results demonstrate important role of MMPs in development of SCCs of lower lip and tongue. PMID: 21255765
    14. MMP-26 expression may be associated with multiple human carcinomas. MMP-26 may also contribute to smooth muscle function in the human prostate and cardiovascular system. PMID: 19895737
    15. role of these proteins in the process of invasion and metastasis cannot be ruled out since their presence is more marked along the tumor invasion front compared to more central areas of squamous cell carcinoma of the tongue PMID: 20491537
    16. GnRH I and II could up-regulate MMP-26 expression through the JNK signaling pathway in human trophoblast-like/trophoblast cells. PMID: 20074375
    17. MMP-26 contributes to tumor cell invasion, migration and angiogenesis PMID: 19956866
    18. MMP-26 expression in stroma is associated with larger Merkel cell carcinoma with poor prognosis. PMID: 19921252
    19. can cleave all subclasses of igG at a specific conserved site PMID: 11841844
    20. role of histidine(81) in mechanism of activation PMID: 11889136
    21. Promoter characterization of the novel human matrix metalloproteinase-26 gene: regulation by the T-cell factor-4 implies specific expression of the gene in cancer cells of epithelial origin. PMID: 11931652
    22. substrate specificity and protein cleavage sites PMID: 12119297
    23. Details of cleavage of pro-MMP-9 by MMP-26, facilitating the efficient cleavage of fibronectin by MMP-9, and promoting invasiveness of ARCaP cells across fibronectin or type IV collagen PMID: 12586837
    24. Present throughout menstrual cycle. Elevated during early to mid-luteal phase. Elevations in users of levonorgestrel implants experiencing irregular uterine bleeding. Seems to play role in hormonal regulation and endometrial tissue remodeling. PMID: 12969699
    25. distinguish shallow, intermediate, and deep S1' pocket characteristics PMID: 14532275
    26. MMP-26 was colocalized with MMP-9, TIMP-2, and TIMP-4 in breast cancer cells. PMID: 14744773
    27. Results suggest a functional relationship between TIMP-4 mRNA and MMP-26 mRNA, and possibly a role in human implantation. PMID: 15273280
    28. Matrilysin-2 overexpression is associated with tumor progression and activation of MMP-9 in esophageal squamous cell carcinoma PMID: 15333466
    29. The expression patterns of MMP26 in human placenta suggests complicated roles for MMP26 during the processes of placentation and hematopoiesis PMID: 15601912
    30. During esophageal tumorigenesis, MMP-21 and MMP-26 have different, unique expression patterns. PMID: 16641547
    31. Maximal expression of MMP-26, in the early and mid-secretory phase suggests its role during implantation and results show it is stored in epithelial cells, is not released spontaneously, and is controlled by TIMP-4 in both stroma and uterine fluid. PMID: 16809379
    32. Results indicate that MMP-26 and TIMP-4 may play an integral role during the conversion of high-grade prostatic intraepithelial neoplasia to invasive cancer and may also serve as markers for early prostate cancer diagnosis. PMID: 16940965
    33. results suggest that MMP-21 and MMP-26 are not only associated with cancer but may be important in connective tissue remodelling and pathobiology of various benign skin disorde PMID: 16984259
    34. A human breast cancer cell linetransfected with wild-type MMP-26 cDNA showed a calcium-dependent invasive potential when compared with controls. PMID: 17176253
    35. The putative role of MMP-26 as a marker of metastasesin pancreatic cancer warrants further studies PMID: 17873896
    36. expression of transmembrane 4 superfamily member 4 (TM4SF4) and matrix metalloproteinase 26 (MMP26) was found to be significantly decreased during the implantation window in patients with polycystic ovary syndrome. PMID: 18765015
    37. MMP-26 may be served as a tumor marker in monitoring progression and predicting prognosis of non-small cell lung cancer. PMID: 19448419
    38. MMP-26 and MMP-9 may contribute to the more aggressive behavior of squamous cell carcinomas in organ transplant recipients PMID: 19674198

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  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Peptidase M10A family
  • 组织特异性：
    Expressed specifically in uterus and placenta. Is also widely expressed in malignant tumors from different sources as well as in diverse tumor cell lines.
  • 数据库链接：

    HGNC: 14249

    OMIM: 605470

    KEGG: hsa:56547

    STRING: 9606.ENSP00000300762

    UniGene: Hs.204732