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  4. Recombinant Human Metallothionein-1M (MT1M)

Recombinant Human Metallothionein-1M (MT1M)

  • 中文名称：
    人MT1M重组蛋白
  • 货号：
    CSB-YP847621HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人MT1M重组蛋白
  • 货号：
    CSB-EP847621HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人MT1M重组蛋白
  • 货号：
    CSB-EP847621HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人MT1M重组蛋白
  • 货号：
    CSB-BP847621HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人MT1M重组蛋白
  • 货号：
    CSB-MP847621HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    MT1M
  • Uniprot No.：
  • 别名：
    MT1M; MT1K; Metallothionein-1M; MT-1M; Metallothionein-IM; MT-IM
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-61
  • 氨基酸序列
    MDPNCSCTTG VSCACTGSCT CKECKCTSCK KSCCSCCPVG CAKCAHGCVC KGTLENCSCC A
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
  • 基因功能参考文献：
    1. Results found that MT1M is downregulated in hepatocellular carcinoma (HCC) tumors, and it suppressed HCC tumorigenesis possibly by inducing cell cycle arrest, enhancing apoptosis and inhibiting cell migration and invasion. These findings provide evidence that MT1M might be a tumor suppressor in HCC tumorigenesis. PMID: 28380433
    2. Low MT1M expression is associated with poor hepatocellular carcinoma prognosis following curative resection. PMID: 27808371
    3. miR-24-3p plays an important role in the initiation and progression of hepatocellular carcinoma by targeting metallothionein 1M. PMID: 27650047
    4. Metallothionein MT1M is a tumor suppressor of human hepatocellular carcinomas. PMID: 22971577
  • 蛋白家族：
    Metallothionein superfamily, Type 1 family
  • 数据库链接：

    HGNC: 14296

    OMIM: 156357

    KEGG: hsa:4499

    STRING: 9606.ENSP00000369146

    UniGene: Hs.647370