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  4. Recombinant Human N-acetylmuramoyl-L-alanine amidase (PGLYRP2)

Recombinant Human N-acetylmuramoyl-L-alanine amidase (PGLYRP2)

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  • 货号：
    CSB-EP846684HU
  • 规格：
    ￥1344
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP846684HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) PGLYRP2.
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP846684HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) PGLYRP2.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    PGLYRP2
  • Uniprot No.：
  • 别名：
    PGLYRP2; PGLYRPL; PGRPL; UNQ3103/PRO10102; N-acetylmuramoyl-L-alanine amidase; EC 3.5.1.28; Peptidoglycan recognition protein 2; Peptidoglycan recognition protein long; PGRP-L
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 来源：
    E.coli
  • 分子量：
    76.0kDa
  • 表达区域：
    22-576aa
  • 氨基酸序列
    SLPLLMDSVIQALAELEQKVPAAKTRHTASAWLMSAPNSGPHNRLYHFLLGAWSLNATELDPCPLSPELLGLTKEVARHDVREGKEYGVVLAPDGSTVAVEPLLAGLEAGLQGRRVINLPLDSMAAPWETGDTFPDVVAIAPDVRATSSPGLRDGSPDVTTADIGANTPDATKGCPDVQASLPDAKAKSPPTMVDSLLAVTLAGNLGLTFLRGSQTQSHPDLGTEGCWDQLSAPRTFTLLDPKASLLTMAFLNGALDGVILGDYLSRTPEPRPSLSHLLSQYYGAGVARDPGFRSNFRRQNGAALTSASILAQQVWGTLVLLQRLEPVHLQLQCMSQEQLAQVAANATKEFTEAFLGCPAIHPRCRWGAAPYRGRPKLLQLPLGFLYVHHTYVPAPPCTDFTRCAANMRSMQRYHQDTQGWGDIGYSFVVGSDGYVYEGRGWHWVGAHTLGHNSRGFGVAIVGNYTAALPTEAALRTVRDTLPSCAVRAGLLRPDYALLGHRQLVRTDCPGDALFDLLRTWPHFTATVKPRPARSVSKRSRREPPPRTLPATDLQ
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-SUMO-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 产品描述：

    This recombinant Human PGLYRP2 protein is an E.coli expressed protein (Full Length of Mature Protein) with N-terminal 6xHis-SUMO tag and its purity is 90%+ determined by SDS-PAGE. With the appropriate cDNA and PCR methods, PGLYRP2 expression plasmids can be rapidly produced. which must undergo denaturation and folding cycle, can be recovered with more modest yields. Hence, using small-scale fermentations and laboratory-scale processing equipment, PGLYRP2 proteins (or subdomains thereof) can usually be produced in sufficient quantities to initiate most studies including detailed structural determinations.which must undergo denaturation and folding cycle, can be recovered with more modest yields. Hence, using small-scale fermentations and laboratory-scale processing equipment, PGLYRP2 proteins (or subdomains thereof) can usually be produced in sufficient quantities to initiate most studies including detailed structural determinations.

    PGLYRP2 is a pattern recognition receptor in the innate immune system that binds, hydrolyzes, and neutralizes proinflammatory bacterial peptidoglycans (PGN). PGLYRP2 is constitutively expressed in the liver and then is released into the blood, where it contributes to regulating the inflammatory response. Expression of PGLYRP2 is induced by bacteria and cytokines in the skin and in epithelial cells. Involvement of PGLYRP2 has been reported in tumor development, immune response in the tumor microenvironment, infectious diseases, inflammatory responses, and brain development.

  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play a scavenger role by digesting biologically active peptidoglycan (PGN) into biologically inactive fragments. Has no direct bacteriolytic activity.
  • 基因功能参考文献：
    1. This study demonistrated that PGLYRP2 single-nucleotide polymorphisms is risk of Parkinson's disease. PMID: 24838182
    2. Various types of human blood cells were tested for expression of the Tag7/PGRP-SA and TagL/PGRP-L proteins, which belong to the family of proteins possessing the lysozyme-like peptidoglycan recognition protein (PGRP) domain PMID: 12669421
    3. Serum N-acetylmuramoyl-l-alanine amidaseand liver PGLYRP2 are the same protein encoded by the pglyrp2 gene. PMID: 16054449
    4. PGLYRP2 may function in the skin and the eyes as an inducible scavenger of proinflammatory peptidoglycan. PMID: 16239516
    5. pglyrp2 expression in skin and liver is important for systemic and local innate immune responses to bacterial infections PMID: 16714290

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  • 亚细胞定位：
    Secreted. Membrane.
  • 蛋白家族：
    N-acetylmuramoyl-L-alanine amidase 2 family
  • 组织特异性：
    Strongly expressed in liver and fetal liver, and secreted into serum. Expressed to a much lesser extent in transverse colon, lymph nodes, heart, thymus, pancreas, descending colon, stomach and testis. Isoform 2 is not detected in the liver or serum.
  • 数据库链接：

    HGNC: 30013

    OMIM: 608199

    KEGG: hsa:114770

    STRING: 9606.ENSP00000345968

    UniGene: Hs.282244