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  4. Recombinant Human Notch homolog 2 N-terminal-like protein (NOTCH2NL)

Recombinant Human Notch homolog 2 N-terminal-like protein (NOTCH2NL)

  • 中文名称：
    人NOTCH2NL重组蛋白
  • 货号：
    CSB-YP768762HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人NOTCH2NL重组蛋白
  • 货号：
    CSB-EP768762HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人NOTCH2NL重组蛋白
  • 货号：
    CSB-EP768762HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人NOTCH2NL重组蛋白
  • 货号：
    CSB-BP768762HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人NOTCH2NL重组蛋白
  • 货号：
    CSB-MP768762HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    NOTCH2NL
  • Uniprot No.：
  • 别名：
    N2N; Notch 2 N terminal like; Notch homolog 2 (Drosophila) N-terminal like; Notch homolog 2 N-terminal-like protein; NOTCH2NL; NT2NL_HUMAN; OTTHUMP00000015593
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-236
  • 氨基酸序列
    MCVTYHNGTG YCKCPEGFLG EYCQHRDPCE KNRCQNGGTC VAQAMLGKAT CRCASGFTGE DCQYSTSHPC FVSRPCLNGG TCHMLSRDTY ECTCQVGFTG KECQWTDACL SHPCANGSTC TTVANQFSCK CLTGFTGQKC ETDVNECDIP GHCQHGGTCL NLPGSYQCQC LQGFTGQYCD SLYVPCAPSP CVNGGTCRQT GDFTFECNCL PETVRRGTEL WERDREVWNG KEHDEN
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway. Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production. Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect. Enhances Notch signaling pathway in a non-cell-autonomous manner via direct interaction with NOTCH2. Also promotes Notch signaling pathway in a cell-autonomous manner through inhibition of cis DLL1-NOTCH2 interactions, which promotes neuronal differentiation.
  • 亚细胞定位：
    Secreted. Cytoplasm.
  • 蛋白家族：
    NOTCH family
  • 组织特异性：
    Widely expressed with higher levels in leukocytes and lymph nodes. Expressed in radial glia neural stem cells during cortical development.
  • 数据库链接：

    HGNC: 31862

    KEGG: hsa:100996717

    STRING: 9606.ENSP00000354929

    UniGene: Hs.655156