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  4. Recombinant Human Nuclear pore complex protein Nup88 (NUP88)

Recombinant Human Nuclear pore complex protein Nup88 (NUP88)

  • 中文名称：
    人NUP88重组蛋白
  • 货号：
    CSB-YP860768HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人NUP88重组蛋白
  • 货号：
    CSB-EP860768HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人NUP88重组蛋白
  • 货号：
    CSB-EP860768HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人NUP88重组蛋白
  • 货号：
    CSB-BP860768HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人NUP88重组蛋白
  • 货号：
    CSB-MP860768HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    88 kDa nucleoporin; karyoporin; Nuclear pore complex protein 88; Nuclear pore complex protein Nup88; Nuclear pore complex protein88; Nucleoporin 88; Nucleoporin 88 kDa; Nucleoporin 88kDa; Nucleoporin Nup88; Nucleoporin88; Nucleoporin88kDa; Nup 84; NUP 88; Nup84; NUP88; NUP88_HUMAN; Prei 2; Prei2; Preimplantation protein 2; Preimplantation protein2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-741
  • 氨基酸序列
    MAAAEGPVGD GELWQTWLPN HVVFLRLREG LKNQSPTEAE KPASSSLPSS PPPQLLTRNV VFGLGGELFL WDGEDSSFLV VRLRGPSGGG EEPALSQYQR LLCINPPLFE IYQVLLSPTQ HHVALIGIKG LMVLELPKRW GKNSEFEGGK STVNCSTTPV AERFFTSSTS LTLKHAAWYP SEILDPHVVL LTSDNVIRIY SLREPQTPTN VIILSEAEEE SLVLNKGRAY TASLGETAVA FDFGPLAAVP KTLFGQNGKD EVVAYPLYIL YENGETFLTY ISLLHSPGNI GKLLGPLPMH PAAEDNYGYD ACAVLCLPCV PNILVIATES GMLYHCVVLE GEEEDDHTSE KSWDSRIDLI PSLYVFECVE LELALKLASG EDDPFDSDFS CPVKLHRDPK CPSRYHCTHE AGVHSVGLTW IHKLHKFLGS DEEDKDSLQE LSTEQKCFVE HILCTKPLPC RQPAPIRGFW IVPDILGPTM ICITSTYECL IWPLLSTVHP ASPPLLCTRE DVEVAESPLR VLAETPDSFE KHIRSILQRS VANPAFLKAS EKDIAPPPEE CLQLLSRATQ VFREQYILKQ DLAKEEIQRR VKLLCDQKKK QLEDLSYCRE ERKSLREMAE RLADKYEEAK EKQEDIMNRM KKLLHSFHSE LPVLSDSERD MKKELQLIPD QLRHLGNAIK QVTMKKDYQQ QKMEKVLSLP KPTIILSAYQ RKCIQSILKE EGEHIREMVK QINDIRNHVN F
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

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靶点详情

  • 功能：
    Component of nuclear pore complex.
  • 基因功能参考文献：
    1. Overexpression of the NUP88 is associated with cancer. PMID: 27636375
    2. Nup88 may be related to the occurrence of endometrial cancers and premalignant lesions PMID: 26839161
    3. These findings demonstrate that the NUP88-NUP98-RAE1-APC/CCDH1 axis contributes to aneuploidy PMID: 26731471
    4. Nup62 and Nup88 protein levels were significantly decreased upon knockdown of O-GlcNAc transferase. PMID: 23777819
    5. Serum Nup88 might be a candidate for a new biomarker implicated in the development and aggressiveness of colorectal cancer PMID: 21863385
    6. Nup88 mRNA was overexpressed in colorectal cancers and the overexpression was associated with cancer development and aggressiveness. PMID: 21896994
    7. Data suggest that a pool of Nup88 on the nuclear side of the nuclear pore complex provides a novel, unexpected binding site for nuclear lamin A. PMID: 21289091
    8. association found between myometrial invasion and Nup88 expression in endometrial carcinoma PMID: 20973273
    9. Gambogic acid exerts its anti-leukemia effects by regulating the expression and distribution of nucleoporin Nup88. PMID: 17828493
    10. proper expression of Nup88 is critical for preventing aneuploidy formation and tumorigenesis. PMID: 20497554
    11. High Nup88 mRNA expression levels correlated with ductal and tubular histology, nuclear grade 3, absence of hormone receptors, expression of c-erb-B2 oncogene and mutant p53 protein, high proliferation, DNA aneuploidy, and axillary node invasion. PMID: 14999780
    12. A monoclonal antibody for Nup88 in an experimental model for studying the role played by Nup88 during cell development and differentiation. PMID: 15300515
    13. the Nup214-Nup88 nucleoporin subcomplex is required for CRM1-mediated 60 S preribosomal nuclear export PMID: 16675447
    14. Our data strongly indicate a dichotomous role for Nup88 in non-neoplastic and neoplastic conditions of the liver. PMID: 17007055
    15. The antitumor activity of deguelin was related to up-regulating the expression of Nup98 and down-regulating Nup88 protein. PMID: 17650673
    16. The formation of high molecular mass complexes containing importin-alpha, Nup153 and Nup88 is increased upon oxidant treatment. PMID: 18068677
    17. Nup88 is up-regulated in response to hypertonic stress and acts to retain TonEBP in the nucleus, activating transcription of critical osmoprotective genes. PMID: 18606815
    18. Nup88 is significantly overexpressed in high-grade CIN lesions and ISCC compared with normal ectocervical squamous epithelia and CIN1. PMID: 19751906

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  • 亚细胞定位：
    Nucleus, nuclear pore complex.
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 8067

    OMIM: 602552

    KEGG: hsa:4927

    STRING: 9606.ENSP00000458954

    UniGene: Hs.584784