Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Human Pancreatic prohormone (PPY)

Recombinant Human Pancreatic prohormone (PPY)

  • 中文名称：
    人PPY重组蛋白
  • 货号：
    CSB-YP018591HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人PPY重组蛋白
  • 货号：
    CSB-EP018591HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人PPY重组蛋白
  • 货号：
    CSB-EP018591HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人PPY重组蛋白
  • 货号：
    CSB-BP018591HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人PPY重组蛋白
  • 货号：
    CSB-MP018591HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PPY
  • Uniprot No.：
  • 别名：
    PPY; PNPPancreatic prohormone; Pancreatic polypeptide; PP; Obinepitide) [Cleaved into: Pancreatic hormone; PH); Pancreatic icosapeptide; PI)]
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Cytoplasmic domain
  • 表达区域：
    30-65
  • 氨基酸序列
    A PLEPVYPGDN ATPEQMAQYA ADLRRYINML TRPRY
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions.; The physiological role for the icosapeptide has not yet been elucidated.
  • 基因功能参考文献：
    1. Fasting human pancreatic polypeptide (HPP) levels are similar in chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma (PDAC) and controls regardless of glycemic status. PMID: 29771765
    2. Because of its properties, the PP appears to be a useful marker of the endocrine insufficiency of the pancreas and a specific prognostic parameter of developing diabetes due to chronic pancreatitis PMID: 26766123
    3. Peptide YY and PP are associated with circulating innate pro-inflammatory cytokines in patients after acute pancreatitis and cumulatively contribute to nearly half of the variance of IL-6, MCP-1, and TNFalpha. Future research is warranted to investigate the signaling pathways that underlie these associations. PMID: 27918953
    4. GIP and pancreatic polypeptide plasma concentrations are lower in pancreatic cancer irrespective of the degree of glucose intolerance as compared to Type 2 diabetic patients and healthy controls. PMID: 28027898
    5. Immunohistochemical distribution of this peptide in the epidermal skin (from abdomen, breast and face) of healthy women was analysed. PMID: 26002416
    6. The most important parameter in diagnosis of HG [Hyperemesis gravidarum ]was plasma PP level PMID: 25990478
    7. These data demonstrate glucose-regulated secretion of PP and its effects on glucagon release through PPYR1 receptors expressed by alpha-cells. PMID: 25445712
    8. Pancreatic polypeptide is recognized by two hydrophobic domains of the human Y4 receptor binding pocket. PMID: 24375409
    9. The diagnostic accuracy of the tumor markers CgA, PP, and glucagon for pancreatic neuroendocrine tumors in multiple endocrine neoplasia type 1 is low. PMID: 23956349
    10. These findings underscore the important role of the NPY-Y receptor system at several levels of the gut-brain axis in which NPY, peptide yy and pancreatic polypeptide operate both as neural and endocrine messengers--{REVIEW} PMID: 22979996
    11. Pancreatic polypeptide (and peptide tyrosine-tyrosine) increases in obese woman on caloric restriction following high protein liquid meals compared to high carbohydrate liquid meals. PMID: 23371976
    12. Data suggest that beta-cell function improves in overweight subjects with type 2 diabetes who lose weight by dieting; this change is associated with a decrease in PPY secretion (i.e., plasma PPY is decreased). PMID: 22673566
    13. Self-association of PPY with phospholipid micelles addressed the delivery issues of the peptide for diabetes treatment. PMID: 22399387
    14. Women with bulimia nervosa have significantly lower fasting and postprandial serum concentrations of pancreatic polypeptide (and GLP-1) than control subjects. PMID: 21813805
    15. Distribution of pancreatic polypeptide and peptide YY PMID: 11825640
    16. Pancreatic polypeptide in pancreatitis PMID: 11825647
    17. Pancreatic polypeptide-related tumors PMID: 11825648
    18. Autonomic neuropathy is associated with impaired neuropeptide Y and this peptide responses to insulin-induced hypoglycaemia in Type I diabetic patients. PMID: 12187924
    19. Early postprandial insulin and PP secretory responses were higher in Pima Indians compared with those of Caucasians. PMID: 14988250
    20. Pancreatic polypeptide contributes to the regulation of energy balance in humans. PMID: 15561938
    21. in healthy humans the presence of fat in the small intestine suppresses ghrelin secretion, and fat-induced suppression of ghrelin and stimulation of peptide YY and pancreatic polypeptide is dependent on fat digestion PMID: 15998659
    22. Inhibits gastric emptying of solid food and delays the postprandial rise in plasma glucose and insulin. Is suggested to have physiological role in pancreatic postprandial counterregulation of gastric emptying and insulin secretion. PMID: 15998783
    23. human pancreatic polypeptide inhibits TFF2 secretion in a diurnal rhythm PMID: 16359755
    24. Age and sex may modulate the association between plasma PP level and the intra-abdominal fat area, suggesting that they may be determinants of parasympathetic activity. PMID: 17171555

    显示更多

    收起更多

  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    NPY family
  • 数据库链接：

    HGNC: 9327

    OMIM: 167780

    KEGG: hsa:5539

    STRING: 9606.ENSP00000225992

    UniGene: Hs.558368