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  4. Recombinant Human Peptidyl-prolyl cis-trans isomerase FKBP10 (FKBP10)

Recombinant Human Peptidyl-prolyl cis-trans isomerase FKBP10 (FKBP10)

  • 中文名称：
    人FKBP10重组蛋白
  • 货号：
    CSB-YP822180HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人FKBP10重组蛋白
  • 货号：
    CSB-EP822180HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人FKBP10重组蛋白
  • 货号：
    CSB-EP822180HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人FKBP10重组蛋白
  • 货号：
    CSB-BP822180HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人FKBP10重组蛋白
  • 货号：
    CSB-MP822180HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    FKBP10; FKBP65; PSEC0056Peptidyl-prolyl cis-trans isomerase FKBP10; PPIase FKBP10; EC 5.2.1.8; 65 kDa FK506-binding protein; 65 kDa FKBP; FKBP-65; FK506-binding protein 10; FKBP-10; Immunophilin FKBP65; Rotamase
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    27-582
  • 氨基酸序列
    VGRG LGRASPAGGP LEDVVIERYH IPRACPREVQ MGDFVRYHYN GTFEDGKKFD SSYDRNTLVA IVVGVGRLIT GMDRGLMGMC VNERRRLIVP PHLGYGSIGL AGLIPPDATL YFDVVLLDVW NKEDTVQVST LLRPPHCPRM VQDGDFVRYH YNGTLLDGTS FDTSYSKGGT YDTYVGSGWL IKGMDQGLLG MCPGERRKII IPPFLAYGEK GYGTVIPPQA SLVFHVLLID VHNPKDAVQL ETLELPPGCV RRAGAGDFMR YHYNGSLMDG TLFDSSYSRN HTYNTYIGQG YIIPGMDQGL QGACMGERRR ITIPPHLAYG ENGTGDKIPG SAVLIFNVHV IDFHNPADVV EIRTLSRPSE TCNETTKLGD FVRYHYNCSL LDGTQLFTSH DYGAPQEATL GANKVIEGLD TGLQGMCVGE RRQLIVPPHL AHGESGARGV PGSAVLLFEV ELVSREDGLP TGYLFVWHKD PPANLFEDMD LNKDGEVPPE EFSTFIKAQV SEGKGRLMPG QDPEKTIGDM FQNQDRNQDG KITVDELKLK SDEDEERVHE EL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    PPIases accelerate the folding of proteins during protein synthesis.
  • 基因功能参考文献：
    1. FKBP10 interacts with collagen VI and deficiency of FKBP10 reduces lung fibroblast migration by down-regulation of collage VI synthesis. PMID: 29673351
    2. Data found novel mutations of the SERPINF1 and FKBP10 genes in Chinese families with autosomal recessive osteogenesis imperfecta PMID: 29512769
    3. an endoplasmic reticulum complex of resident chaperones that includes HSP47, FKBP65, and BiP regulating the activity of LH2. PMID: 28177155
    4. FKBP10 protein is overexpressed in renal cell carcinoma PMID: 27602571
    5. FKBP65 is linked to pyridinoline cross-linking by specifically mediating the dimerization of LH2. PMID: 27298363
    6. novel pathogenic mutations of FKBP10 can lead to the extremely rare type XI Osteogenesis imperfecta without contractures, which expands the genotypic spectrum of Osteogenesis imperfecta. PMID: 27762305
    7. Mutations in FKBP10, localised to chromosome 17q21, have been identified in a patient of Bruck syndrome. Additional cases are also discussed. PMID: 25931047
    8. A pathogenic change was found in the FKBP10 gene in patients with osteogenesis imperfecta. PMID: 27706701
    9. findings further extend the body of evidence that supports the importance of FKBP10 gene in the development of skeletal system PMID: 26538303
    10. Mutations in the HSP47 and FKBP65 produce a moderately severe form of Osteogenesis imperfect. PMID: 25510505
    11. CTSD, FKBP10, and SLC2A1 are novel genes that participate in the acquisition and maintenance of the adriamycin-resistant phenotype in leukemia cells. PMID: 24467213
    12. Results imply that FKBP10 mutations affect collagen indirectly, by ablating FKBP65 support for collagen telopeptide hydroxylation by lysyl hydroxylase 2, thus decreasing collagen cross-links in tendon and bone matrix. PMID: 23712425
    13. Elastin binding protein and FKBP65 modulate the kinetics of self-assembly of tropoelastin in an in vitro system. PMID: 24106871
    14. FKBP10 depletion enhances glucocerebrosidase proteostasis in Gaucher disease fibroblasts PMID: 23434032
    15. underexpression of FKBP65 protein is characteristic of high-grade serous carcinomas and this expression profile may be linked to molecular pathways associated with an unfavourable outcome in cancer patients. PMID: 23354471
    16. FKBP10 acts during procollagen maturation to contribute to molecular stability and post-translational modification of type I procollagen, without which bone mass and quality are abnormal and fractures and contractures result PMID: 22949511
    17. identified a Palestinian pedigree with moderate and lethal forms of recessive OI caused by mutations in FKBP10 or PPIB, which encode endoplasmic reticulum resident chaperone/isomerases FKBP65 and CyPB, respectively PMID: 22718341
    18. Homozygosity mapping identified FKBP10 as a candidate gene, and sequencing revealed a base pair exchange that causes a C-terminal premature stop codon in this gene. PMID: 22107750
    19. Mutations in FKBP10 cause both Bruck syndrome and isolated osteogenesis imperfecta in humans. PMID: 21567934
    20. The differential expression of FKBP65 indicates a role in ovarian physiology as well as in ovarian tumor development PMID: 21399973
    21. FKBP10 mutations are a cause of recessive osteogenesis imperfecta and Bruck syndrome. PMID: 20839288
    22. Mutations in the gene encoding the RER protein FKBP65 cause autosomal-recessive osteogenesis imperfecta. PMID: 20362275

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  • 相关疾病：
    Osteogenesis imperfecta 11 (OI11); Bruck syndrome 1 (BRKS1)
  • 亚细胞定位：
    Endoplasmic reticulum lumen.
  • 数据库链接：

    HGNC: 18169

    OMIM: 259450

    KEGG: hsa:60681

    STRING: 9606.ENSP00000317232

    UniGene: Hs.463035