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  4. Recombinant Human Phosducin-like protein 3 (PDCL3)

Recombinant Human Phosducin-like protein 3 (PDCL3)

  • 中文名称：
    人PDCL3重组蛋白
  • 货号：
    CSB-YP872479HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人PDCL3重组蛋白
  • 货号：
    CSB-EP872479HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人PDCL3重组蛋白
  • 货号：
    CSB-EP872479HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人PDCL3重组蛋白
  • 货号：
    CSB-BP872479HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人PDCL3重组蛋白
  • 货号：
    CSB-MP872479HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PDCL3
  • Uniprot No.：
  • 别名：
    HTPHLP; IAP associated factor VIAF1; MGC3062; PDCL 3; Pdcl3; PDCL3_HUMAN; PHLP2A; PHLP3; Phosducin like 3; Phosducin like protein 3; Phosducin-like protein 3; PhPL3; VIAF 1; VIAF; VIAF-1; VIAF1; Viral IAP associated factor 1; Viral IAP-associated factor 1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-239
  • 氨基酸序列
    MQDPNADTEW NDILRKKGIL PPKESLKELE EEAEEEQRIL QQSVVKTYED MTLEELEDHE DEFNEEDERA IEMYRRRRLA EWKATKLKNK FGEVLEISGK DYVQEVTKAG EGLWVILHLY KQGIPLCALI NQHLSGLARK FPDVKFIKAI STTCIPNYPD RNLPTIFVYL EGDIKAQFIG PLVFGGMNLT RDELEWKLSE SGAIMTDLEE NPKKPIEDVL LSSVRRSVLM KRDSDSEGD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation. Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding. Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes. Modulates the activation of caspases during apoptosis.
  • 基因功能参考文献：
    1. results have shown that PhLP2A interacts with Hsp90 and exhibits molecular chaperone activity toward denatured proteins. PMID: 27496612
    2. The data provide new insights for the chaperone function of PDCL3 in angiogenesis and the roles of hypoxia and N-terminal methionine acetylation in PDCL3 expression and its effect on VEGFR-2. PMID: 26059764
    3. data provide strong evidence for the role of PDCL3 in angiogenesis and establishes the molecular mechanism by which it regulates VEGFR-2 expression and function. PMID: 23792958
    4. Data support a model in which Plp2p modulates the biogenesis of several CCT substrates relating to cell cycle and cytoskeletal function, which together contribute to the essential function of PLP2. PMID: 17429077
    5. This publication pertains to mouse. PMID: 12424248

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, perinuclear region. Endoplasmic reticulum.
  • 蛋白家族：
    Phosducin family
  • 组织特异性：
    Expressed in endothelial cells (at protein level). Expressed in all tissues examined including spleen, thymus, prostate, testis, ovary, small intestine and colon.
  • 数据库链接：

    HGNC: 28860

    OMIM: 611678

    KEGG: hsa:79031

    STRING: 9606.ENSP00000264254

    UniGene: Hs.469459