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  4. Recombinant Human Plasma cell-induced resident endoplasmic reticulum protein (PACAP)

Recombinant Human Plasma cell-induced resident endoplasmic reticulum protein (PACAP)

  • 中文名称：
    人MZB1重组蛋白
  • 货号：
    CSB-YP855472HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人MZB1重组蛋白
  • 货号：
    CSB-EP855472HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人MZB1重组蛋白
  • 货号：
    CSB-EP855472HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人MZB1重组蛋白
  • 货号：
    CSB-BP855472HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人MZB1重组蛋白
  • 货号：
    CSB-MP855472HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    MZB1
  • Uniprot No.：
  • 别名：
    MZB1; Caspase 2 binding protein; FLJ32987; HSPC190; Marginal zone B and B1 cell specific protein; Marginal zone B- and B1-cell-specific protein; MEDA 7; MEDA-7; Mesenteric estrogen dependent adipose 7; Mesenteric estrogen-dependent adipose 7; Mesenteric oestrogen dependent adipose gene 7; MGC29506; Mzb1; MZB1_HUMAN; PACAP; pERp1; Plasma cell-induced ER protein 1; Plasma cell-induced resident endoplasmic reticulum protein; Plasma cell-induced resident ER protein; Proapoptotic caspase adapter protein
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    23-189
  • 氨基酸序列
    DRAPLTAT APQLDDEEMY SAHMPAHLRC DACRAVAYQM WQNLAKAETK LHTSNSGGRR ELSELVYTDV LDRSCSRNWQ DYGVREVDQV KRLTGPGLSE GPEPSISVMV TGGPWPTRLS RTCLHYLGEF GEDQIYEAHQ QGRGALEALL CGGPQGACSE KVSATREEL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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靶点详情

  • 功能：
    Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity. Isoform 2 may be involved in regulation of apoptosis. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation.; Acts as a hormone-regulated adipokine/proinflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance.
  • 基因功能参考文献：
    1. expression was positively correlated with a high accumulation of CD8(+) tumor-infiltrating lymphocytes in pancreatic ductal adenocarcinoma after neoadjuvant chemoradiotherapy PMID: 29180208
    2. Low MZB1 expression was an independent prognostic factor for recurrence after curative gastrectomy and was associated significantly with increased hematogenous recurrence. MZB1 acts as a suppressor of GC. Low MZB1 expression in the primary GC tissue is predictive of recurrence after curative resection. PMID: 27459504
    3. High expression of MZB1 predicts adverse prognosis in chronic lymphocytic leukemia, follicular lymphoma and diffuse large B-cell lymphoma and is associated with a unique gene expression signature. PMID: 23189934
    4. miR-185 regulates T cell development through its targeting of several mRNAs including Mzb1. PMID: 24014023
    5. results suggested that MGC29506 has the potential of functioning as a novel suppressor gene in gastric cancer PMID: 23434460
    6. methylation-mediated silencing of MZB1 expression leads to loss of its tumor-suppressive activity, which may be a factor in hepatocarcinogenesis PMID: 22573353
    7. Data show that proapoptotic caspase adapter protein PACAP is a potential serum marker of non-small cell lung cancer. PMID: 22613335
    8. MGC29506 gene, frequently down-regulated in intestinal-type gastric cancer, was found to encode secreted-type protein with six conserved cysteine residues [MGC29506] PMID: 12792799

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  • 亚细胞定位：
    [Isoform 1]: Endoplasmic reticulum lumen. Secreted.; [Isoform 2]: Cytoplasm. Note=Diffuse granular localization in the cytoplasm surrounding the nucleus (PubMed:11350957).
  • 蛋白家族：
    MZB1 family
  • 组织特异性：
    Widely expressed with highest levels in adult brain, small intestine and lymphoid tissues such as thymus and spleen. Expression is frequently lower in intestinal-type gastric cancer. In obese patients, more abundant in omental than in subcutaneous fat.
  • 数据库链接：

    HGNC: 30125

    OMIM: 609447

    KEGG: hsa:51237

    STRING: 9606.ENSP00000303920

    UniGene: Hs.409563