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  4. Recombinant Human Pleckstrin homology domain-containing family B member 2 (PLEKHB2)

Recombinant Human Pleckstrin homology domain-containing family B member 2 (PLEKHB2)

  • 中文名称：
    人PLEKHB2重组蛋白
  • 货号：
    CSB-YP846599HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人PLEKHB2重组蛋白
  • 货号：
    CSB-EP846599HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人PLEKHB2重组蛋白
  • 货号：
    CSB-BP846599HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人PLEKHB2重组蛋白
  • 货号：
    CSB-MP846599HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PLEKHB2
  • Uniprot No.：
  • 别名：
    Evectin 2; Evectin-2; Evectin2; EVT2; FLJ20783; FLJ23679; FLJ30436; PH domain containing family B member 2; PH domain-containing family B member 2; PKHB2_HUMAN; Pleckstrin homology domain containing family B member 2; Pleckstrin homology domain containing, family B (evectins) member 2; Pleckstrin homology domain-containing family B member 2; Plekhb2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-222
  • 氨基酸序列
    MAFVKSGWLL RQSTILKRWK KNWFDLWSDG HLIYYDDQTR QNIEDKVHMP MDCINIRTGQ ECRDTQPPDG KSKDCMLQIV CRDGKTISLC AESTDDCLAW KFTLQDSRTN TAYVGSAVMT DETSVVSSPP PYTAYAAPAP EQAYGYGPYG GAYPPGTQVV YAANGQAYAV PYQYPYAGLY GQQPANQVII RERYRDNDSD LALGMLAGAA TGMALGSLFW VF
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in retrograde transport of recycling endosomes.
  • 基因功能参考文献：
    1. Knockdown of evectin-2 (a recycling endosome-resident protein) suppresses nuclear localization of YAP and YAP-dependent transcription. Evectin-2 knockdown reduces the ubiquitination and increased the level of Lats1. PMID: 29093443
    2. The crystal structure at 1.75 A resolution of an apo form of human evectin-2 pleckstrin homology domain, in which the ligand-binding site is free from crystal packing and is thus appropriate for comparison with the structure of the complex, is reported. PMID: 22281740
    3. Data show that depletion of evt-2 or masking of intracellular PS suppressed membrane traffic from REs to the Golgi. PMID: 21911378
  • 亚细胞定位：
    Recycling endosome membrane; Peripheral membrane protein. Note=Specifically detected in tubulovesicular structures, and colocalizes with TFNR.
  • 数据库链接：

    HGNC: 19236

    KEGG: hsa:55041

    STRING: 9606.ENSP00000385892

    UniGene: Hs.469944