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  4. Recombinant Human Postacrosomal sheath WW domain-binding protein (WBP2NL)

Recombinant Human Postacrosomal sheath WW domain-binding protein (WBP2NL)

  • 中文名称：
    人WBP2NL重组蛋白
  • 货号：
    CSB-YP750315HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人WBP2NL重组蛋白
  • 货号：
    CSB-EP750315HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人WBP2NL重组蛋白
  • 货号：
    CSB-EP750315HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人WBP2NL重组蛋白
  • 货号：
    CSB-BP750315HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人WBP2NL重组蛋白
  • 货号：
    CSB-MP750315HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    WBP2NL
  • Uniprot No.：
  • 别名：
    WBP2NL; PAWPPostacrosomal sheath WW domain-binding protein; WW domain-binding protein 2-like
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-309
  • 氨基酸序列
    MAVNQSHTEN RRGALIPNGE SLLKRSPNVE LSFPQRSEGS NVFSGRKTGT LFLTSYRVIF ITSCSISDPM LSFMMPFDLM TNLTVEQPVF AANFIKGTIQ AAPYGGWEGQ ATFKLVFRNG DAIEFAQLMV KAASAAARGF PLRTLNDWFS SMGIYVITGE GNMCTPQMPC SVIVYGAPPA GYGAPPPGYG APPAGYGAQP VGNEGPPVGY RASPVRYGAP PLGYGAPPAG YGAPPLGYGA PPLGYGTPPL GYGAPPLGYG APPAGNEGPP AGYRASPAGS GARPQESTAA QAPENEASLP SASSSQVHS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play a role in meotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization.
  • 基因功能参考文献：
    1. Taken into account that WBP2NL/PAWP gene and protein levels and distribution did not correlate with fertilization rates, this study questions the interest of WBP2NL/PAWP protein and gene expression analysis in sperm cells as a prognostic factor for the outcome of ICSI cycles PMID: 28444612
    2. High fertilization (56.06%) and pregnancy (41.7%) rates accomplished in this study following ICSI-AOA indicated that expression profiles of PLCzeta, PAWP, and TR-KIT were low in globozoospermic individuals PMID: 27089467
    3. Conclude that human PAWP is neither sufficient nor necessary for the Ca(2+) oscillations that initiate mammalian oocyte activation at fertilization. PMID: 26116451
    4. WBP2NL might play roles as an anti-apoptotic factor or co-activator to promote breast cancer cell survival and proliferation. PMID: 25417742
    5. Demonstrate significant correlations between sperm PAWP levels and both fertilization rates and normal embryonic development after intracytoplasmic sperm injection. PMID: 24907910

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  • 组织特异性：
    Expressed in testis.
  • 数据库链接：

    HGNC: 28389

    OMIM: 610981

    KEGG: hsa:164684

    STRING: 9606.ENSP00000328800

    UniGene: Hs.655541