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  4. Recombinant Human Potassium voltage-gated channel subfamily E member 1-like protein (KCNE1L), partial

Recombinant Human Potassium voltage-gated channel subfamily E member 1-like protein (KCNE1L), partial

  • 中文名称：
    人KCNE5重组蛋白
  • 货号：
    CSB-YP891715HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人KCNE5重组蛋白
  • 货号：
    CSB-EP891715HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人KCNE5重组蛋白
  • 货号：
    CSB-EP891715HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人KCNE5重组蛋白
  • 货号：
    CSB-BP891715HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人KCNE5重组蛋白
  • 货号：
    CSB-MP891715HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    KCNE5
  • Uniprot No.：
  • 别名：
    KCNE5; AMMECR2; KCNE1L; Potassium voltage-gated channel subfamily E regulatory beta subunit 5; AMME syndrome candidate gene 2 protein; Potassium channel subunit beta MiRP4; Potassium voltage-gated channel subfamily E member 1-like protein
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Potassium channel ancillary subunit that is essential for generation of some native K(+) currents by virtue of formation of heteromeric ion channel complex with voltage-gated potassium (Kv) channel pore-forming alpha subunits. Functions as an inhibitory beta-subunit of the repolarizing cardiac potassium ion channel KCNQ1.
  • 基因功能参考文献：
    1. common single nucleotide polymorphism (SNP) from KCNE5, and ECG measurements and survival in postacute acute coronary syndrome patients PMID: 21985337
    2. Data show that KCNQ3 and KCNE5 mRNA expressions were significantly upregulated in preeclampsia. PMID: 21730298
    3. KCNE5 modulates I(to), and its novel variants appeared to cause IVF, especially BrS, in male patients through gain-of-function effects on I(to). Screening for KCNE5 variants is relevant for BrS or IVF. PMID: 21493962
    4. A missense mutation in KCNE5 may be associated with nonfamilial or acquired forms of atrial fibrillation. PMID: 18313602
  • 相关疾病：
    Alport syndrome with mental retardation, midface hypoplasia and elliptocytosis (ATS-MR)
  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Potassium channel KCNE family
  • 组织特异性：
    Highly expressed in heart, skeletal muscle, brain, spinal cord and placenta.
  • 数据库链接：

    HGNC: 6241

    OMIM: 300194

    KEGG: hsa:23630

    STRING: 9606.ENSP00000361173

    UniGene: Hs.522753