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  4. Recombinant Human Probable proline dehydrogenase 2 (PRODH2)

Recombinant Human Probable proline dehydrogenase 2 (PRODH2)

  • 中文名称：
    人PRODH2重组蛋白
  • 货号：
    CSB-YP880073HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人PRODH2重组蛋白
  • 货号：
    CSB-EP880073HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人PRODH2重组蛋白
  • 货号：
    CSB-EP880073HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人PRODH2重组蛋白
  • 货号：
    CSB-BP880073HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人PRODH2重组蛋白
  • 货号：
    CSB-MP880073HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PRODH2
  • Uniprot No.：
  • 别名：
    HsPOX1; Kidney and liver proline oxidase 1; Probable proline dehydrogenase 2; Probable proline oxidase 2; PROD2_HUMAN; PRODH2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-536
  • 氨基酸序列
    MSPRVVSNSS VLASQSVGIT NVRTVFSNVF NNTTAFPILR GSNCHKITAP GLGKGQLVNL LPPENLPWCG GSQGPRMLRT CYVLCSQAGP PSRGWQSLSF DGGAFHLKGT GELTRALLVL RLCAWPPLVT HGLLLQAWSR RLLGSRLSGA FLRASVYGQF VAGETAEEVK GCVQQLRTLS LRPLLAVPTE EEPDSAAKSG EAWYEGNLGA MLRCVDLSRG LLEPPSLAEA SLMQLKVTAL TSTRLCKELA SWVRRPGASL ELSPERLAEA MDSGQNLQVS CLNAEQNQHL RASLSRLHRV AQYARAQHVR LLVDAEYTSL NPALSLLVAA LAVRWNSPGE GGPWVWNTYQ ACLKDTFERL GRDAEAAHRA GLAFGVKLVR GAYLDKERAV AQLHGMEDPT QPDYEATSQS YSRCLELMLT HVARHGPMCH LMVASHNEES VRQATKRMWE LGIPLDGTVC FGQLLGMCDH VSLALGQAGY VVYKSIPYGS LEEVIPYLIR RAQENRSVLQ GARREQELLS QELWRRLLPG CRRIPH
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Dehydrogenase that converts trans-4-L-hydroxyproline to delta-1-pyrroline-3-hydroxy-5-carboxylate (Hyp) using ubiquinone-10 as the terminal electron acceptor. Can also use proline as a substrate but with a very much lower efficiency. Does not react with other diastereomers of Hyp: trans-4-D-hydroxyproline and cis-4-L-hydroxyproline. Ubiquininone analogs such as menadione, duroquinone and ubiquinone-1 react more efficiently than oxygen as the terminal electron acceptor during catalysis.
  • 基因功能参考文献：
    1. Data suggest that residues 157-515 of PRODH2 contain catalytic core with one FAD molecule; PRODH2 most likely utilizes coenzyme Q10 as terminal electron acceptor in vivo; PRODH2 exhibits substrate specificity for hydroxyproline over proline. PMID: 25697095
    2. PRODH, but not PRODH2, expression is under the control of p53 family members, specifically p53 and p73. PMID: 23861960
    3. OH-POX plays a role analogous to POX in growth regulation, ROS generation, and activation of the apoptotic cascade PMID: 18287100
  • 蛋白家族：
    Proline oxidase family
  • 数据库链接：

    HGNC: 17325

    OMIM: 616377

    KEGG: hsa:58510

    STRING: 9606.ENSP00000301175

    UniGene: Hs.515366