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  4. Recombinant Human Proline-rich membrane anchor 1 (PRIMA1), partial

Recombinant Human Proline-rich membrane anchor 1 (PRIMA1), partial

  • 中文名称：
    人PRIMA1重组蛋白
  • 货号：
    CSB-YP771468HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人PRIMA1重组蛋白
  • 货号：
    CSB-EP771468HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人PRIMA1重组蛋白
  • 货号：
    CSB-EP771468HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人PRIMA1重组蛋白
  • 货号：
    CSB-BP771468HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人PRIMA1重组蛋白
  • 货号：
    CSB-MP771468HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PRIMA1
  • Uniprot No.：
  • 别名：
    PRiMA; PRIMA_HUMAN; Prima1; Proline-rich membrane anchor 1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Required to anchor acetylcholinesterase (ACHE) to the basal lamina of the neuromuscular junction and to the membrane of neuronal synapses in brain. Also able to organize ACHE into tetramers.
  • 基因功能参考文献：
    1. Methylation of SFRP1, SFRP2, SDC2, and PRIMA1 promoter sequences was observed in 85.1%, 72.3%, 89.4%, and 80.9% of plasma samples from patients with Colorectal cancer and 89.2%, 83.8%, 81.1% and 70.3% from adenoma patients, respectively. PMID: 28753106
    2. PRIMA-1 could cause the demethylation of TP73, through DNMT1 depletion, to subsequently enhance the unfolded protein response PMID: 27533450
    3. Silencing of CD24 enhanced restoration of PRIMA-1-induced mutant p53 in endogenous TP53(P223L/V274F) DU145 cells. PMID: 26712693
    4. The results suggest that aberrant methylation of rDNA and PRIMA1 is associated with the pathogenesis of Borderline Personality Disorder. PMID: 26742039
    5. Hypermethylation of the selected markers (MAL, PRIMA1, PTGDR and SFRP1) can result in reduced gene expression and may contribute to the formation of colorectal cancer. PMID: 26482433
    6. The autophagic potential of PRIMA-1 could be modulated in a different way by the presence of wild type or mutant p53. PMID: 23545415
    7. By using site-directed mutagenesis, the asparagine-43 was identified to be the N-linked glycosylation site of PRiMA. Abolishing glycosylation on mouse PRiMA appeared not to affect its assembly with AChE(T). PMID: 22750213
    8. A strong association of AChE with PRiMA at the plasma membrane is therefore a feature specific to principal cholinergic neurons that innervate the central nervous system. PMID: 20471375
    9. PRiMA in neurons has a role in targeting acetylcholinesterase to membrane rafts PMID: 20147288
    10. PRiMA-Luc promotor-driven luciferase activity was increased during cell differentiation PMID: 16429581
    11. These results suggested that a MAP kinase signaling pathway served as one of the transcriptional regulators in controlling PRiMA gene expression during the neuronal differentiation process. PMID: 19368807

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Cell junction. Cell junction, synapse.
  • 数据库链接：

    HGNC: 18319

    OMIM: 613851

    KEGG: hsa:145270

    STRING: 9606.ENSP00000376848

    UniGene: Hs.432401