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  4. Recombinant Human Prorelaxin H2 (RLN2)

Recombinant Human Prorelaxin H2 (RLN2)

  • 中文名称：
    人RLN2重组蛋白
  • 货号：
    CSB-YP019750HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人RLN2重组蛋白
  • 货号：
    CSB-EP019750HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人RLN2重组蛋白
  • 货号：
    CSB-EP019750HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人RLN2重组蛋白
  • 货号：
    CSB-BP019750HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人RLN2重组蛋白
  • 货号：
    CSB-MP019750HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    H2; REL2_HUMAN; Relaxin 2; Relaxin A chain; Relaxin H2; RLN2; RLXH2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    25-185aa
  • 氨基酸序列
    DSWMEEVIKLCGRELVRAQIAICGMSTWSKRSLSQEDAPQTPRPVAEIVPSFINKDTETINMMSEFVANLPQELKLTLSEMQPALPQLQQHVPVLKDSSLLFEEFKKLIRNRQSEAADSSPSELKYLGLDTHSRKKRQLYSALANKCCHVGCTKRSLARFC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.
  • 基因功能参考文献：
    1. Data indicate that the small proportion of acute heart failure (AHF) patients achieving relaxin-2 concentrations similar to those observed in pregnancy may survive longer. PMID: 29716428
    2. RL2 level was inversely related to the severity of the atherosclerotic disease; studies with a larger cohort incorporating a consistent study population are warranted to verify results and shed light on the mechanistic background of these processes PMID: 29565035
    3. High RNL2 expression is associated with Neuroblastoma. PMID: 29695398
    4. The aim of this study was to investigate plasma levels of relaxin-2 in patients with gestational diabetes mellitus, in comparison to pregnant controls without diabetes. PMID: 28664310
    5. Second trimester serum concentrations of proRLX2 are not predictive of the development of preeclampsia in pregnancy. PMID: 29133069
    6. Opposite actions of urotensin II and relaxin-2 on cellular expression of fibronectin in renal fibrosis PMID: 28613403
    7. Relaxin-2 significantly upregulated intracellular processes in human female ACL cells, but no effect was observed in male cells. Relaxin increased MMP (MMP1 and MMP3) and decreased alphaSMA and type I and III collagen expression, which may act to alter the structural integrity of the ACL tissue over time. PMID: 27245459
    8. Data suggest that enhanced survival of normal prostate epithelial cells (PNT1A cell line) in presence of either or both angiotensin II (Ang II) and relaxin 2 (RLN2) appears to be associated with increased ratio of BCL2/BAX messenger RNA expression; thus, Ang II and/or RLN2 appear to be involved in regulation of apoptosis in prostate epithelium. PMID: 27119161
    9. Relaxin in the hypothalamic paraventricular nucleus contributes to sympathetic overdrive and hypertension via PI3K-Akt pathway. PMID: 26746861
    10. serelaxin differentially modulates vascular tone in different vascular beds PMID: 26493539
    11. The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1 has been deciphered. PMID: 27088579
    12. Relaxin Inhibits High Glucose-Induced Matrix Accumulation in Human Mesangial Cells by Interfering with TGFB1 Production and Mesangial Cells Phenotypic Transition PMID: 26424011
    13. the correlation between RLN2 and p-AKT or RLN2 and p-ERK1/2 expression was investigated. PMID: 26229955
    14. Effects of RLX on the electrical properties of cardiac stromal cell membrane correlate well with its well-known ability to suppress myofibroblast differentiation, supporting the possibility that RLX may be used for the treatment of cardiac fibrosis. PMID: 25786395
    15. H2 relaxin is fully active at the relaxin receptor RXFP1 and thus dimerization is not required for biological activity. PMID: 25547165
    16. Synthetic covalently linked dimeric form of H2 relaxin retains native RXFP1 activity and has improved in vitro serum stability. PMID: 25685807
    17. Overexpression of RLN2 and S100A4 might be related to the prediction of metastasis potency and poor prognosis for osteosarcoma patients. PMID: 25339476
    18. Benefits of relaxin-2 treatment in hypertension include reduced ADMA levels and increased NO bioavailability, possibly due to its antioxidant effects. PMID: 25298524
    19. we demonstrated distinct patterns of signalling for H3 and H2 relaxin and R3(BDelta23-27)R/I5 at the RXFP3 receptor PMID: 24641548
    20. Intravenous injection of serelaxin (recombinant relaxin 2) results in prolonged bradykinin-mediated vasorelaxation is principally mediated through prostacyclin. PMID: 24584737
    21. Relaxin-2 or relaxin-3 levels are not related to component traits in patients with diabetes. PMID: 23994775
    22. serum relaxin-2 may have a role in progression esophageal squamous cell carcinoma PMID: 23613637
    23. SNP rs4742076 in the RLN2 promoter was associated with increased dRLN expression and PPROM; SNP rs3758239 was associated with both PPROM and spontaneous preterm birth in these Filipino patients. PMID: 23727041
    24. overexpression of relaxin-2 protein in hepatocellular carcinoma (HCC) tissues is of predictive value on tumor progression and poor prognosis. PMID: 23661524
    25. This review provides information on the structure and function of relaxin and its receptors. Furthermore, we present evidence of the involvement of these elements in the process of cancerogenesis. PMID: 23668059
    26. Identification of key residues essential for the structural fold and receptor selectivity within the A-chain of human gene-2 (H2) relaxin PMID: 23024363
    27. Our data support a novel role for the RLN2 ligand-receptor system at the ocular surface and in the lacrimal apparatus as a potential future therapeutic during wound healing at the ocular surface. PMID: 23111608
    28. Skeletal myoblasts engineered to express RLN2 promote myocardial viability and performance improvement post-myocardial infarction. PMID: 22949764
    29. The role of the pleiotropic peptide hormone, human relaxin-2 in cancer. [Review] PMID: 22855207
    30. relaxin-2 and its receptors RXFP1 and RXFP2 are expressed in GSV and their expression is significantly decreased in varicose GSV PMID: 22737225
    31. Relaxin significantly increased the MMP-1 and MMP-8 expression in a time-dependent manner in human periodontal ligament cells in vitro. PMID: 22141456
    32. Recombinant H2 relaxin selectively inhibits apoptosis by down-regulating caspse-3 expression and induces proliferation in cultured human leiomyoma cells without affecting apoptosis or proliferation in normal myometrial cells. PMID: 22226177
    33. H2-RLX could give play to the antifibrotic effects by repressing the fibroblast proliferation and transdifferentiation for myofibroblast in systemic sclerosis. PMID: 22152813
    34. The mean serum relaxin concentrations for athletes with anterior cruciate ligament tears was significantly higher than that for those without anterior cruciate ligament tears. PMID: 21737831
    35. The minimal active structure of human relaxin-2. PMID: 21878627
    36. The combined data indicate RLN2 overexpression is frequent in prostate cancer patients PMID: 21789713
    37. Stable RLN2 transfectants secreted enhanced levels of bioactive MMP2 which contributed to the increased collagenolytic activity and in vitro invasiveness into collagen matrix by human thyroid cancer cells. PMID: 21493587
    38. Women homozygous for prevalent SNPs in the RLN2 gene may have a genetic susceptibility for preterm birth. PMID: 20023247
    39. Expression, purification and characterization of human prorelaxin-like-protein H2 in Escherichia coli PMID: 12198562
    40. regulates fibrillin 2, but not fibrillin 1, mRNA and protein expression by human dermal fibroblasts and murine fetal skin PMID: 12590922
    41. Relaxin stimulates new blood vessel formation and increases cytokine-containing lymphocyte number while maintaining endometrial connective tissue integrity. PMID: 15070778
    42. No difference in bioactivity was detected between porcine relaxin-1 and recombinant human relaxin-2 in either mice or rats PMID: 15956696
    43. Adenovirus-mediated delivery of human H2 preprorelaxin (hH2) to the brain is capable of producing bioactive relaxin that affects cardiovascular parameters PMID: 15956711
    44. relaxin 2 can increase Cyclic AMP via Gs-adenylate cyclase pathway PMID: 15956719
    45. Although all cell types expressed mRNA for the relaxin receptor (LGR7), only peripheral blood mononuclear cells responded to relaxin 2 at physiologic levels by increasing tumor necrosis factor-alpha and interleukin-1beta secretion PMID: 15956727
    46. characterization of upregulated H2 relaxin gene expression during neuroendocrine differentiation of the human prostate cancer model, LNCaP PMID: 15956728
    47. Relaxin is a potent antifibrotic hormone with a rapid-occurring efficacy that may have therapeutic potential for hypertensive disease. PMID: 15967869
    48. study provides the first account of a potential role of H2 relaxin in prostate tumor development PMID: 16049981
    49. The structural-functional organization of the adenylyl cyclase signaling mechanism due to the action of human relaxin 2 was deciphered. PMID: 16580233
    50. Relaxin enhances the oncogenic potential and acts as novel endocrine modulator of invasiveness in human thyroid carcinoma cells. PMID: 16877360

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Insulin family
  • 组织特异性：
    Isoform 1 is expressed in the ovary during pregnancy. Also expressed in placenta, decidua and prostate. Isoform 2 is relatively abundant in placenta. It is in much lower abundance in the prostate gland. Not detected in the ovary.
  • 数据库链接：

    HGNC: 10027

    OMIM: 179740

    KEGG: hsa:6019

    STRING: 9606.ENSP00000371040

    UniGene: Hs.127032