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  4. Recombinant Human Ras-related protein Rap-2c (RAP2C)

Recombinant Human Ras-related protein Rap-2c (RAP2C)

  • 中文名称：
    人RAP2C重组蛋白
  • 货号：
    CSB-YP896507HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人RAP2C重组蛋白
  • 货号：
    CSB-EP896507HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人RAP2C重组蛋白
  • 货号：
    CSB-EP896507HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人RAP2C重组蛋白
  • 货号：
    CSB-BP896507HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人RAP2C重组蛋白
  • 货号：
    CSB-MP896507HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    RAP2C
  • Uniprot No.：
  • 别名：
    2010200P20Rik; AI194294; AL022976; BOS_25229; DKFZp313B211; MGC143331; OTTHUMP00000024037; OTTMUSP00000019067; RAP2C; RAP2C; member of RAS oncogene family; RAP2C_HUMAN; Ras related protein Rap 2c; Ras-related protein Rap-2c; RP23-15D12.2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-180
  • 氨基酸序列
    MREYKVVVLG SGGVGKSALT VQFVTGTFIE KYDPTIEDFY RKEIEVDSSP SVLEILDTAG TEQFASMRDL YIKNGQGFIL VYSLVNQQSF QDIKPMRDQI VRVKRYEKVP LILVGNKVDL EPEREVMSSE GRALAQEWGC PFMETSAKSK SMVDELFAEI VRQMNYSSLP EKQDQCCTTC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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靶点详情

  • 功能：
    Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May play a role in SRE-mediated gene transcription.
  • 基因功能参考文献：
    1. Study found that SCII upregulated the expression of miR-204 and downregulated the expression of RAP2C; that hypoxia increased the expression of miR-204 and decreased the expression of RAP2C, and overexpression of RAP2C attenuates the effect of hypoxia on apoptosis rate; and miR-204 could directly bind to RAP2C, and could regulate the expression of RAP2C. PMID: 28714326
    2. JAM-A regulates epithelial permeability via association with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and control contraction of the apical cytoskeleton. PMID: 23885123
    3. This work demonstrates that Rap2C is a new member of the Rap2 subfamily of proteins, able to bind guanine nucleotides with peculiar properties, and differently expressed by various hematopoietic subsets PMID: 16213650
    4. RAP2C is a novel member of the Ras family, belonging to the Rap branch of small GTPase proteins and may be involved in SRE-mediated gene transcription. PMID: 17447155
  • 亚细胞定位：
    Cytoplasm. Recycling endosome membrane; Lipid-anchor; Cytoplasmic side.
  • 蛋白家族：
    Small GTPase superfamily, Ras family
  • 组织特异性：
    Expressed in liver, skeletal muscle, prostate, uterus, rectum, stomach, and bladder and to a lower extent in brain, kidney, pancreas, and bone marrow. Expressed in mononuclear leukocytes and megakaryocytes.
  • 数据库链接：

    HGNC: 21165

    KEGG: hsa:57826

    STRING: 9606.ENSP00000340274

    UniGene: Hs.119889