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  4. Recombinant Human Regulator of G-protein signaling 7-binding protein (RGS7BP)

Recombinant Human Regulator of G-protein signaling 7-binding protein (RGS7BP)

  • 中文名称：
    人RGS7BP重组蛋白
  • 货号：
    CSB-YP747223HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人RGS7BP重组蛋白
  • 货号：
    CSB-EP747223HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人RGS7BP重组蛋白
  • 货号：
    CSB-EP747223HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人RGS7BP重组蛋白
  • 货号：
    CSB-BP747223HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人RGS7BP重组蛋白
  • 货号：
    CSB-MP747223HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    RGS7BP
  • Uniprot No.：
  • 别名：
    RGS7BP; R7BP; Regulator of G-protein signaling 7-binding protein; R7 family-binding protein
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-257
  • 氨基酸序列
    MSSAPNGRKK RPSRSTRSSI FQISKPPLQS GDWERRGSGS ESAHKTQRAL DDCKMLVQEF NTQVALYREL VISIGDVSVS CPSLRAEMHK TRTKGCEMAR QAHQKLAAIS GPEDGEIHPE ICRLYIQLQC CLEMYTTEML KSICLLGSLQ FHRKGKEPGG GTKSLDCKIE ESAETPALED SSSSPVDSQQ HSWQVSTDIE NTERDMREMK NLLSKLRETM PLPLKNQDDS SLLNLTPYPL VRRRKRRFFG LCCLISS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Regulator of G protein-coupled receptor (GPCR) signaling. Regulatory subunit of the R7-Gbeta5 complexes that acts by controlling the subcellular location of the R7-Gbeta5 complexes. When palmitoylated, it targets the R7-Gbeta5 complexes to the plasma membrane, leading to inhibit G protein alpha subunits. When it is unpalmitoylated, the R7-Gbeta5 complexes undergo a nuclear/cytoplasmic shuttling. May also act by controlling the proteolytic stability of R7 proteins, probably by protecting them from degradation.
  • 基因功能参考文献：
    1. Data (including data from studies using transgenic mice) suggest that R7BP-RGS7 heterotrimers interact with Galpha13 to augment signaling pathways in neurons that regulate neurite morphogenesis. (R7BP = RGS7 family binding protein; RGS7 = regulator of G-protein signaling 7 protein; Galpha13 = GTP-binding protein alpha subunit 13) PMID: 28432124
    2. R7-binding protein had a strong inhibitory effect on homo-oligomerization of RGS7. PMID: 26895961
    3. BL3-ht2 of RGS7BP may be an important genetic variant associated with AERD. The haplotype of block 3 may play a protective role against aspirin hypersensitivity in asthma, perhaps by altering the responsiveness of muscarinic receptors. PMID: 21457877
    4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
    5. cytoplasmic RGS7*Gbeta5*R7BP heterotrimers and RGS7*Gbeta5 heterodimers are equivalently inefficient regulators of G protein-coupled receptor signaling relative to plasma membrane-bound heterotrimers bearing palmitoylated R7BP. PMID: 16867977
    6. the successful purification of functionally intact Gbeta5-free recombinant RGS11 was reported that differentially interact with R7BP and Galpha(oa). PMID: 19497306

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Cell membrane; Lipid-anchor.
  • 蛋白家族：
    RGS7BP/RGS9BP family
  • 数据库链接：

    HGNC: 23271

    OMIM: 610890

    KEGG: hsa:401190

    STRING: 9606.ENSP00000334851

    UniGene: Hs.657133