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  4. Recombinant Human SH3 and cysteine-rich domain-containing protein 3 (STAC3)

Recombinant Human SH3 and cysteine-rich domain-containing protein 3 (STAC3)

  • 中文名称：
    人STAC3重组蛋白
  • 货号：
    CSB-YP839373HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人STAC3重组蛋白
  • 货号：
    CSB-EP839373HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人STAC3重组蛋白
  • 货号：
    CSB-EP839373HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人STAC3重组蛋白
  • 货号：
    CSB-BP839373HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人STAC3重组蛋白
  • 货号：
    CSB-MP839373HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    STAC3
  • Uniprot No.：
  • 别名：
    MGC2793; SH3 and cysteine rich domain 3; SH3 and cysteine rich domain-containing protein 3; SH3 and cysteine-rich domain-containing protein 3; stac3; STAC3_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-364
  • 氨基酸序列
    MTEKEVLESP KPSFPAETRQ SGLQRLKQLL RKGSTGTKEM ELPPEPQANG EAVGAGGGPI YYIYEEEEEE EEEEEEPPPE PPKLVNDKPH KFKDHFFKKP KFCDVCARMI VLNNKFGLRC KNCKTNIHEH CQSYVEMQRC FGKIPPGFHR AYSSPLYSNQ QYACVKDLSA ANRNDPVFET LRTGVIMANK ERKKGQADKK NPVAAMMEEE PESARPEEGK PQDGNPEGDK KAEKKTPDDK HKQPGFQQSH YFVALYRFKA LEKDDLDFPP GEKITVIDDS NEEWWRGKIG EKVGFFPPNF IIRVRAGERV HRVTRSFVGN REIGQITLKK DQIVVQKGDE AGGYVKVYTG RKVGLFPTDF LEEI
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Required for normal excitation-contraction coupling in skeletal muscle and for normal muscle contraction in response to membrane depolarization. Required for normal Ca(2+) release from the sarcplasmic reticulum, which ultimately leads to muscle contraction. Probably functions via its effects on muscle calcium channels. Increases CACNA1S channel activity, in addition to its role in enhancing the expression of CACNA1S at the cell membrane. Has a redundant role in promoting the expression of the calcium channel CACNA1S at the cell membrane. Slows down the inactivation rate of the calcium channel CACNA1C.
  • 基因功能参考文献：
    1. STAC3 mutation is associated with overlapping features of Carey-Fineman-Ziter syndrome and Moebius syndrome. PMID: 28777491
    2. A mutation in human STAC3 is the genetic basis of the debilitating Native American myopathy. PMID: 23736855
  • 相关疾病：
    Native American myopathy (NAM)
  • 亚细胞定位：
    Cytoplasm. Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Cell membrane, sarcolemma, T-tubule.
  • 数据库链接：

    HGNC: 28423

    OMIM: 255995

    KEGG: hsa:246329

    STRING: 9606.ENSP00000329200

    UniGene: Hs.417595