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  4. Recombinant Human Sodium/bile acid cotransporter (SLC10A1), partial

Recombinant Human Sodium/bile acid cotransporter (SLC10A1), partial

  • 中文名称：
    人SLC10A1重组蛋白
  • 货号：
    CSB-YP623947HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SLC10A1重组蛋白
  • 货号：
    CSB-EP623947HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人SLC10A1重组蛋白
  • 货号：
    CSB-EP623947HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SLC10A1重组蛋白
  • 货号：
    CSB-BP623947HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人SLC10A1重组蛋白
  • 货号：
    CSB-MP623947HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Cell growth-inhibiting gene 29 protein; GIG29; Growth inhibiting protein 29; Na / bile acid cotransporter; Na / taurocholate transport protein; Na(+)/bile acid cotransporter; Na(+)/taurocholate transport protein; Na/taurocholate cotransporting polypeptide; NTCP; NTCP_HUMAN; NTCP1; SLC10A1; Sodium/bile acid cotransporter; Sodium/taurocholate cotransporter polypeptide, hepatic; Sodium/taurocholate cotransporting polypeptide; Solute carrier family 10 (sodium/bile acid cotransporter family) member 1; Solute carrier family 10 member 1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium.; (Microbial infection) Acts as a receptor for hepatitis B virus.
  • 基因功能参考文献：
    1. we review the current knowledge of the functional role and the molecular and cellular biology of NTCP in the life cycle of the three major hepatotropic viruses, highlight the impact of NTCP as an antiviral target and discuss future avenues of research PMID: 30097692
    2. In this study, the s identified new hepatitis B virus isolates from one homozygous S267F NTCP mutation carrier and confirmed new isolates also use wildtype-NTCP as a cellular receptor. Furthermore, we demonstrated S267F variant of NTCP, though inefficient, is still a functional receptor for hepatitis B virus entry. PMID: 30032030
    3. These findings suggest that host factors unique to HepaRG cells are required for efficient infection by serum-derived HBV, and factors other than NTCP contribute to balanced viral antigen production following infection by cell culture-derived HBV. PMID: 29793953
    4. These kinetic results provide important complementary data on the substrate selectivity and specificity of NTCP to transport bile acids. PMID: 29024779
    5. Results show that NTCP inhibition suppressed the in vivo spread of HBV infection in the presence of uninfected hepatocytes. Livers in CHB patients contained varying degrees of HBsAg-negative hepatocytes, as evidenced by immunohistochemistry. PMID: 27278060
    6. These results uncover NTCP as a mediator of innate antiviral immune responses in the liver. PMID: 27783949
    7. For Tibetans and Uygurs, no association of the three NTCP SNPs (rs7154439, rs4646287 and rs2296651) and their haplotypes with hepatitis B virus chronicity was observed. PMID: 27051045
    8. the present study indicated that the common variants in the regulatory elements of NTCP may not influence the expression level of SLC10A1 at transcriptional regulation, and ultimately may not be associated with HBV susceptibility. PMID: 27491457
    9. The data showed that S267F of sodium taurocholate cotransporting polypeptide is not associated with hepatitis B virus infection, and is not prevalent in the general Moroccan population. PMID: 28125961
    10. The SLC10A1 (NTCP) S267F variant is independently associated with decreased risk of progression to Liver cirrhosis and Hepatocellular Carcinoma , and resistance to Chronic Hepatitis B infection. PMID: 26642861
    11. In conclusion, NTCP appeared inefficient to mediate infection by serum-derived hepatitis B virus. PMID: 27384660
    12. Computer screening of NTCP inhibitors and non-inhibitors showed no relationship between the drugs and drug induced liver injury. PMID: 25220493
    13. We found a genetic variant (rs4646287) located in intron 1 of NTCP that may be associated with increased risk of HBV infection in Han Chinese PMID: 26968990
    14. The observation that the pharmacological inhibitors of the NTCP transporter could block HBV entry suggests that NTCP represents an attractive molecular target for therapeutic intervention in HBV infection. PMID: 25929767
    15. Hepatitis B virus efficiently infects non-adherent hepatoma cells via NTCP, which functions as a virus receptor. PMID: 26592202
    16. We describe for the first time a mouse liver cell line that, solely upon expression of the hNTCP receptor, becomes susceptible to HBV. PMID: 26865711
    17. This study suggests that polymorphisms in the NTCP region may be associated with the natural course of HBV infection. PMID: 25010264
    18. Liver nuclear receptors, FXR and SHP, and bile acid transporters, NTCP and BSEP, are associated with the progression of NAFLD. PMID: 26019035
    19. Interleukin 6 inhibits HBV entry through downregulation of NTCP. PMID: 25765005
    20. NTCP is a functional receptor for hepatitis B virus and hepatitis D virus. PMID: 25409679
    21. NTCP polymorphism play a critical role in the individual variability of rosuvastatin pharmacokinetics in Chinese healthy males PMID: 25985569
    22. NTCP is a functional receptor for human hepatitis B and D virus. PMID: 23150796
    23. hNTCP is an electrogenic Na(+)-dependent transporter PMID: 25168282
    24. findings suggest that the rs2296651 polymorphism in NTCP may predispose the susceptibility to and chronicity of HBV infection PMID: 24735529
    25. Viral entry of hepatitis B and D viruses and bile salts transportation share common molecular determinants on NTCP. PMID: 24390325
    26. Human NTCP is a specific receptor for hepatitis B and D viruses, allowing virus entry into hepatocytes. PMID: 24361467
    27. Polymorphisms in CYP2C9, CYP2C19 and SLC10A1 had minimal lipid-lowering effects. PMID: 23930675
    28. Knockdown analysis suggested that HBV infection of HepG2-hNTCP-C4 cells was mediated by NTCP. PMID: 24342612
    29. This study was conducted to determine which of the 8 cysteine residues of NTCP is responsible for nitric oxide-mediated S-nitrosylation and inhibition of taurocholate uptake. PMID: 23886862
    30. Data suggest that, in SLC10A1, amino acid residues along one face of transmembrane domain 5 do not play direct role in substrate transport but are critical for sodium/bile acid transport functions of SLC10A1, most likely through helical stability. PMID: 23815591
    31. these results suggest that the plasma membrane localization rather than kinase activity of PKCdelta plays an important role in cAMP-induced NTCP translocation and Rab4 activity PMID: 22744337
    32. Patients undergoing partial hepatectomy with low post-operative bilirubin had lower levels of NTCP, MDR3 and BSEP mRNA compared to those with high bilirubin after Pringle manoeuvre. PMID: 22098322
    33. NTCP adopts a dimeric structure in which individual subunits are functional. Bile salt uptake is influenced by heterodimerization when this impairs NTCP plasma membrane trafficking. PMID: 22029531
    34. essential role of Na+-taurocholate co-transporting polypeptide (NTCP) in the uptake of bile acids, by which the enterohepatic recirculation of bile acids is maintained PMID: 21341987
    35. Inhibition of taurocholate uptake by nitric oxide involves S-nitrosylation of NTCP. PMID: 21109590
    36. The mRNA expression levels of sodium taurocholate cotransporting polypeptide, bile salt export pump, and hepatic cholesterol 7alpha-hydroxylase were significantly higher in the primary biliary cirrhosis patients than in the controls. PMID: 20857261
    37. Translation/insertion scanning, alanine insertion, and glycosylation site mutagenesis studies of liver sodium/bile acid cotransporter support a topography with nine membrane-spanning or membrane-associated segments. PMID: 12044156
    38. a domain critical for bile acid substrate recognition of SLC10A1 has an ethnicity-dependent polymorphism PMID: 14660639
    39. Conserved NTCP/Ntcp 5'-regulatory region transcription regulation differs among species and is not directly regulated by small heterodimer partner. Bile acids may regulate NTCP/Ntcp indirectly by modulating nuclear factor regulation of gene expression. PMID: 14701722
    40. The present studies were undertaken to establish a suitable in vitro experimental model to study human ASBT function and its regulation by cholesterol. PMID: 15604201
    41. The major canalicular transporter genes are expressed at mid-gestational stage during human fetal development. PMID: 15922475
    42. Results suggest that the Ser-226 in the third cytoplasmic loop of NTCP is phosphorylated and cAMP may increase NTCP translocation to the cell membrane by dephosphorylating NTCP at this site. PMID: 16027164
    43. The GR/dexamethasone activation of the hNTCP promoter is counteracted by bile acids and small heterodimer partner, providing a negative feedback mechanism for bile acid uptake in human hepatocytes. PMID: 16123152
    44. Cholesterol treatment led to increased levels of NTCP and OCT-1 mRNAs. PMID: 17635184

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Bile acid:sodium symporter (BASS) (TC 2.A.28) family
  • 数据库链接：

    HGNC: 10905

    OMIM: 182396

    KEGG: hsa:6554

    STRING: 9606.ENSP00000216540

    UniGene: Hs.952