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  4. Recombinant Human Suppressor APC domain-containing protein 2 (SAPCD2)

Recombinant Human Suppressor APC domain-containing protein 2 (SAPCD2)

  • 中文名称：
    人SAPCD2重组蛋白
  • 货号：
    CSB-YP801230HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SAPCD2重组蛋白
  • 货号：
    CSB-EP801230HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人SAPCD2重组蛋白
  • 货号：
    CSB-EP801230HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SAPCD2重组蛋白
  • 货号：
    CSB-BP801230HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人SAPCD2重组蛋白
  • 货号：
    CSB-MP801230HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SAPCD2
  • Uniprot No.：
  • 别名：
    SAPCD2; C9orf140; Suppressor APC domain-containing protein 2; Tumor specificity and mitosis phase-dependent expression protein; TS/MDEP; p42.3
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-394
  • 氨基酸序列
    MAGAAMAERG RVPPPAPAPS TEGLPRAFLQ SLRTLFDILD DRRRGCVHLR EIESRWQGTD ARELPRGVLE GLRQVAPASG YLTFERFVAG LRTSLLSADG GPRDPTRAPA RPGDQPPPPP QRLVFAPADE PRTVLERKPL PLGVRAPLAG PSAAARSPEQ LCAPAEAAPC PAEPERSQSA ALEPSSSADA GAVACRALEA DSGDARRAPR ARGERRRHTI ASGVDCGLLK QMKELEQEKE VLLQGLEMMA RGRDWYQQQL QRVQERQRRL GQSRASADFG AAGSPRPLGR LLPKVQEVAR CLGELLAAAC ASRALPPSSS GPPCPALTST SPPVWQQQTI LMLKEQNRLL TQEVTEKSER ITQLEQEKSA LIKQLFEARA LSQQDGGPLD STFI
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a role in planar mitotic spindle orientation in retinal progenitor cells (RPCs) and promotes the production of symmetric terminal divisions. Negatively regulates the mitotic apical cortex localization of GPSM2. Involved also in positive regulation of cell proliferation and tumor cell growth.
  • 基因功能参考文献：
    1. Data show that overexpressed p42.3 protein is correlated with gastric cancer cell proliferation, migration, and invasion, suggesting its use as a biological marker in gastric cancer. PMID: 27449033
    2. p42.3 protein was related to the occurrence and development of gastric carcinoma. PMID: 27461626
    3. p42.3 gene expression is associated with gastric mucosal inflammation that can be upregulated by TNF-alpha and H. pylori infection. PMID: 26316259
    4. results uncover SAPCD2 as a key regulator of the ternary complex controlling spindle orientation during morphogenesis and asymmetric cell divisions PMID: 26766442
    5. p42.3 has a role in the pathogenesis of gastric carcinoma PMID: 26106439
    6. Overexpression of the p42.3 gene is associated with gliomas. PMID: 24927751
    7. Role of C9orf140 in the promotion of colorectal cancer progression and mechanisms of its upregulation via activation of STAT5, beta-catenin and EZH2. PMID: 24608043
    8. p42.3 overexpression is associated with mitotic progression in malignant transformed cells. PMID: 23192843
    9. Up-regulation of p42.3 in hepatocellular carcinoma promotes tumorigenicity and tumor growth. PMID: 23704824
    10. p42.3 might play an important role in the progression of colorectal cancer. PMID: 23576022
    11. p42.3 protein plays an important role in the generation and development of gastric cancer. PMID: 23228105
    12. the regulatory relationship between miRNAs and the p42.3 gene PMID: 21998710

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Cytoplasm, cell cortex. Apical cell membrane. Cell junction, tight junction.
  • 组织特异性：
    Expressed in 5-month-old fetal tissues, including stomach, intestine, colon, liver, brain, lung, heart, spleen and kidney. Undetectable in non-cancerous adult tissues. Expressed in many primary gastric carcinoma, but almost not in adjacent normal mucosa.
  • 数据库链接：

    HGNC: 28055

    OMIM: 612057

    KEGG: hsa:89958

    STRING: 9606.ENSP00000386348

    UniGene: Hs.19322