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  4. Recombinant Human Synaptotagmin-11 (SYT11), partial

Recombinant Human Synaptotagmin-11 (SYT11), partial

  • 中文名称：
    人SYT11重组蛋白
  • 货号：
    CSB-YP883595HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SYT11重组蛋白
  • 货号：
    CSB-EP883595HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人SYT11重组蛋白
  • 货号：
    CSB-EP883595HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SYT11重组蛋白
  • 货号：
    CSB-BP883595HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人SYT11重组蛋白
  • 货号：
    CSB-MP883595HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SYT11
  • Uniprot No.：
  • 别名：
    DKFZp781D015; KIAA0080; MGC10881; MGC17226; Synaptotagmin 11; Synaptotagmin 12; Synaptotagmin XI; Synaptotagmin-11; Synaptotagmin11; Synaptotagmin12; SynaptotagminXI; SYT 11; SYT 12; Syt XI; Syt11; SYT11_HUMAN; SYT12; SytXI
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Synaptotagmin family member involved in vesicular and membrane trafficking which does not bind Ca(2+). Inhibits clathrin-mediated and bulk endocytosis, functions to ensure precision in vesicle retrieval. Plays an important role in dopamine transmission by regulating endocytosis and the vesicle-recycling process. Essential component of a neuronal vesicular trafficking pathway that differs from the synaptic vesicle trafficking pathway but is crucial for development and synaptic plasticity. In macrophages and microglia, inhibits the conventional cytokine secretion, of at least IL6 and TNF, and phagocytosis. In astrocytes, regulates lysosome exocytosis, mechanism required for the repair of injured astrocyte cell membrane. Required for the ATP13A2-mediated regulation of the autophagy-lysosome pathway.
  • 基因功能参考文献：
    1. ATP13A2 and SYT11 form a functional network in the regulation of the autophagy-lysosome pathway, which may contribute to forms of Parkinson's Disease-associated neurodegeneration. PMID: 27278822
    2. parkin deficiency induces synaptotagmin-11 accumulation and PD-like neurotoxicity in mouse models, which is reversed by SYT11 knockdown in the SNpc or knockout of SYT11 restricted to dopaminergic neuron PMID: 29311685
    3. In summary, This study supports the existence of association between Parkinson disease and markers in or around SYT11 PMID: 26944171
    4. The genetic variations of VAMP2, Synaptotagmin XI might be indication of the relationship between these genes and idiopathic generalized epilepsy PMID: 24164654
    5. parkin interacts with and ubiquitinates synaptotagmin XI PMID: 12925569
    6. Lack of disease-causing mutations in a detailed analysis of a large sample of familial and sporadic Parkinson's disease patients argues against a major role of mutations in the synaptotagmin XI gene in PD. PMID: 15354386
    7. Excessive expression of Syt11 can be associated with schizophrenia. PMID: 17192956

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  • 亚细胞定位：
    Cytoplasmic vesicle membrane; Single-pass membrane protein. Perikaryon. Golgi apparatus, trans-Golgi network membrane; Single-pass membrane protein. Recycling endosome membrane; Single-pass membrane protein. Lysosome membrane; Single-pass membrane protein. Cytoplasmic vesicle, phagosome. Cell projection, axon. Cell projection, dendrite. Cell junction, synapse, postsynaptic density. Recycling endosome membrane; Single-pass membrane protein. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Single-pass membrane protein. Perikaryon.
  • 蛋白家族：
    Synaptotagmin family
  • 数据库链接：

    HGNC: 19239

    OMIM: 608741

    KEGG: hsa:23208

    STRING: 9606.ENSP00000357307

    UniGene: Hs.32984