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  4. Recombinant Human TFIIA-alpha and beta-like factor (GTF2A1L)

Recombinant Human TFIIA-alpha and beta-like factor (GTF2A1L)

  • 中文名称：
    人GTF2A1L重组蛋白
  • 货号：
    CSB-YP891567HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人GTF2A1L重组蛋白
  • 货号：
    CSB-EP891567HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人GTF2A1L重组蛋白
  • 货号：
    CSB-EP891567HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人GTF2A1L重组蛋白
  • 货号：
    CSB-BP891567HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人GTF2A1L重组蛋白
  • 货号：
    CSB-MP891567HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    GTF2A1L
  • Uniprot No.：
  • 别名：
    GTF2A1L; ALF; GTF2A1LF; TFIIA-alpha and beta-like factor; General transcription factor II A; 1-like factor
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-478
  • 氨基酸序列
    MACLNPVPKL YRSVIEDVIE GVRNLFAEEG IEEQVLKDLK QLWETKVLQS KATEDFFRNS IQSPLFTLQL PHSLHQTLQS STASLVIPAG RTLPSFTTAE LGTSNSSANF TFPGYPIHVP AGVTLQTVSG HLYKVNVPIM VTETSGRAGI LQHPIQQVFQ QLGQPSVIQT SVPQLNPWSL QATTEKSQRI ETVLQQPAIL PSGPVDRKHL ENATSDILVS PGNEHKIVPE ALLCHQESSH YISLPGVVFS PQVSQTNSNV ESVLSGSASM AQNLHDESLS TSPHGALHQH VTDIQLHILK NRMYGCDSVK QPRNIEEPSN IPVSEKDSNS QVDLSIRVTD DDIGEIIQVD GSGDTSSNEE IGSTRDADEN EFLGNIDGGD LKVPEEEADS ISNEDSATNS SDNEDPQVNI VEEDPLNSGD DVSEQDVPDL FDTDNVIVCQ YDKIHRSKNK WKFYLKDGVM CFGGRDYVFA KAIGDAEW
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May function as a testis specific transcription factor. Binds DNA in conjunction with GTF2A2 and TBP (the TATA-binding protein) and together with GTF2A2, allows mRNA transcription.
  • 基因功能参考文献：
    1. Our results provided a new insight into susceptibility of USF1 variant with male infertility. rs11204546 of OR2W3 and rs11677854 of GTF2A1L might be additional valuable molecular predictive markers PMID: 25374392
    2. A unique CpG-specific methylation pattern at the ALF promoter precedes expression in pachytene spermatocytes. PMID: 11889132
    3. Results identified ALF as a human spermatogenesis related gene, the abnormal expression of ALF might be the partial cause for human infertility. PMID: 16525715
    4. TFIIA tau is associated with undifferentiated cells during development, yet is down-regulated at the chromatin level upon cellular differentiation. PMID: 16646664
  • 亚细胞定位：
    Nucleus. Note=Mainly localizes in the annulus and partly in acrosomal cap area of spermatozoa.
  • 蛋白家族：
    TFIIA subunit 1 family
  • 组织特异性：
    Testis specific. Detected in adult testis mostly in round and elongating spermatids (at protein level). Detected in testis.
  • 数据库链接：

    HGNC: 30727

    OMIM: 605358

    KEGG: hsa:11036

    STRING: 9606.ENSP00000384597

    UniGene: Hs.732016