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  4. Recombinant Human TNFAIP3-interacting protein 2 (TNIP2)

Recombinant Human TNFAIP3-interacting protein 2 (TNIP2)

  • 中文名称：
    人TNIP2重组蛋白
  • 货号：
    CSB-YP822786HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人TNIP2重组蛋白
  • 货号：
    CSB-EP822786HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人TNIP2重组蛋白
  • 货号：
    CSB-EP822786HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人TNIP2重组蛋白
  • 货号：
    CSB-BP822786HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人TNIP2重组蛋白
  • 货号：
    CSB-MP822786HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    TNIP2
  • Uniprot No.：
  • 别名：
    A20 binding inhibitor of NF kappaB activation 2; A20-binding inhibitor of NF-kappa-B activation 2; ABIN 2; ABIN-2; Fetal liver LKB1-interacting protein; FLIP1; KLIP; LKB1 interacting protein; TNFAIP3 interacting protein 2; TNFAIP3-interacting protein 2; TNIP2; TNIP2_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-429
  • 氨基酸序列
    MSRDPGSGGW EEAPRAAAAL CTLYHEAGQR LRRLQDQLAA RDALIARLRA RLAALEGDAA PSLVDALLEQ VARFREQLRR QEGGAAEAQM RQEIERLTER LEEKEREMQQ LLSQPQHERE KEVVLLRRSM AEGERARAAS DVLCRSLANE THQLRRTLTA TAHMCQHLAK CLDERQHAQR NVGERSPDQS EHTDGHTSVQ SVIEKLQEEN RLLKQKVTHV EDLNAKWQRY NASRDEYVRG LHAQLRGLQI PHEPELMRKE ISRLNRQLEE KINDCAEVKQ ELAASRTARD AALERVQMLE QQILAYKDDF MSERADRERA QSRIQELEEK VASLLHQVSW RQDSREPDAG RIHAGSKTAK YLAADALELM VPGGWRPGTG SQQPEPPAEG GHPGAAQRGQ GDLQCPHCLQ CFSDEQGEEL LRHVAECCQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes.
  • 基因功能参考文献：
    1. RelAp43 interacts with the p105-ABIN2-TPL2 complex and we observe a strong perturbation of this complex in presence of M protein. PMID: 29084252
    2. Study reports the crystal structure of hABIN2 in complex with linear triubiquitin, which shows the ubiquitins with M1-linkage could form a right-handed helical trimer when bridging two hABIN2 dimers, and thus allow the assembly of a higher-order signaling complex with A20. PMID: 27916521
    3. Findings suggest an expanded role for the NF-kappaB network hub protein TNIP2 and reveals an association between TNIP2 and YLPM1, TNIP2 and ESCRT-I, together with many RNA processing proteins and a distinct set of mRNAs. PMID: 27609421
    4. miR-1180 might act as a tumor promoter by targeting TNIP2 during development of hepatocellular carcinoma. PMID: 27044843
    5. ABIN-2 acts as a positive regulator of NF-kappaB-dependent transcription by activating IKKalpha. PMID: 21784860
    6. A20, ABIN-1/2, and CARD11 mutations have prognostic value in gastrointestinal diffuse large B-cell lymphoma PMID: 21266526
    7. transcription repressed by promyelocytic leukemia protein expression PMID: 12080044
    8. FLIP1 has a role in the regulation of NF-kappaB activity related to the role of LKB1 in tumor suppression PMID: 12595760
    9. Endothelial tyrosine kinase Tie2 interacts with ABIN-2. PMID: 12609966
    10. ABIN-2 exerts unexpected function in mediating transcriptional coactivation. PMID: 12753905
    11. ABIN-2 was found to inhibit endothelial apoptosis and rescue cells from death following growth factor deprivation. Deletion of the carboxy-terminus of ABIN-2 removed its ability to inhibit apoptosis. PMID: 12933576
    12. optimal TPL-2 stability in vivo requires interaction with ABIN-2 as well as p105 PMID: 15169888
    13. ABIN-2 may function as a negative regulator that downregulates NF-kappaB activation during liver regeneration PMID: 16480954
    14. Thus, CIH-mediated NF-kappaB activation may be a molecular mechanism linking OSA and cardiovascular pathologies seen in OSA patients. PMID: 16554025
    15. Thus the present results showed a correlation between NF-kappaB activation and the repair of sublethal damage in split-dose irradiation. PMID: 17038805
    16. role for an ABIN-sensitive non-classical NF-kappaB signalling pathway in the proliferation of EGFR-overexpressing tumour cells. PMID: 18622428
    17. This review defines ABIN-2 based on three different parameters: ability to bind A20; ability to inhibit NF-kappaB activation upon overexpression; the presence of specific short amino acid regions of strong homology, designated ABIN homology domains. PMID: 19464428

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 组织特异性：
    Ubiquitously expressed in all tissues examined.
  • 数据库链接：

    HGNC: 19118

    OMIM: 610669

    KEGG: hsa:79155

    STRING: 9606.ENSP00000321203

    UniGene: Hs.368551