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  4. Recombinant Human TRAF3-interacting protein 1 (TRAF3IP1)

Recombinant Human TRAF3-interacting protein 1 (TRAF3IP1)

  • 中文名称：
    人TRAF3IP1重组蛋白
  • 货号：
    CSB-YP848411HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人TRAF3IP1重组蛋白
  • 货号：
    CSB-EP848411HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人TRAF3IP1重组蛋白
  • 货号：
    CSB-EP848411HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人TRAF3IP1重组蛋白
  • 货号：
    CSB-BP848411HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人TRAF3IP1重组蛋白
  • 货号：
    CSB-MP848411HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    TRAF3IP1
  • Uniprot No.：
  • 别名：
    Interleukin 13 receptor alpha 1 binding protein 1; Interleukin-13 receptor alpha 1-binding protein 1; Microtubule interacting protein that associates with TRAF3; Microtubule-interacting protein associated with TRAF3; MIP T3; MIP-T3; MIPT3; MIPT3_HUMAN; TNF receptor associated factor 3 interacting protein 1; TRAF3-interacting protein 1; Traf3ip1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-691
  • 氨基酸序列
    MNAAVVRRTQ EALGKVIRRP PLTEKLLSKP PFRYLHDIIT EVIRMTGFMK GLYTDAEMKS DNVKDKDAKI SFLQKAIDVV VMVSGEPLLA KPARIVAGHE PERTNELLQI IGKCCLNKLS SDDAVRRVLA GEKGEVKGRA SLTSRSQELD NKNVREEESR VHKNTEDRGD AEIKERSTSR DRKQKEELKE DRKPREKDKD KEKAKENGGN RHREGERERA KARARPDNER QKDRGNRERD RDSERKKETE RKSEGGKEKE RLRDRDRERD RDKGKDRDRR RVKNGEHSWD LDREKNREHD KPEKKSASSG EMSKKLSDGT FKDSKAETET EISTRASKSL TTKTSKRRSK NSVEGRKEDN ISAKSLDSIV SGINNEPNQE TTTSEIGTKE ANINSTSISD DNSASLRCEN IQPNPTEKQK GDSTSDAEGD AGPAGQDKSE VPETPEIPNE LSSNIRRIPR PGSARPAPPR VKRQDSMEAL QMDRSGSGKT VSNVITESHN SDNEEDDQFV VEAAPQLSEM SEIEMVTAVE LEEEEKHGGL VKKILETKKD YEKLQQSPKP GEKERSLFES AWKKEKDIVS KEIEKLRTSI QTLCKSALPL GKIMDYIQED VDAMQNELQM WHSENRQHAE ALQQEQRITD CAVEPLKAEL AELEQLIKDQ QDKICAVKAN ILKNEEKIQK MVYSINLTSR R
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules. Involved in kidney development and epithelial morphogenesis. Involved in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels. Involved in ciliogenesis.
  • 基因功能参考文献：
    1. Mutations in TRAF3IP1 are identified in patients with nephronophthisis and retinal degeneration. The identified mutations result in mild ciliary defects in patients and reveal a role of IFT54 as a negative regulator of microtubule stability via MAP4. PMID: 26487268
    2. MIP-T3 functions as a negative regulator of the innate type I interferon response by preventing TRAF3 from forming protein complexes with critical downstream transducers and effectors of antiviral response. PMID: 22079989
    3. Data show that MIP-T3 protein level is highly regulated; mainly mediated by the ubiquitin-proteasome system. PMID: 21510943
    4. The interaction of MIP-T3 with both actin filaments and microtubule suggested that MIP-T3 may play an important role in regulation of cytoskeleton dynamics in cells. PMID: 20391533
    5. These results suggest that MIP-T3 is a novel inhibitor of IL-13 signaling and may be a useful molecule in ameliorating various conditions in which IL-13 plays a central role. PMID: 12935900

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  • 相关疾病：
    Senior-Loken syndrome 9 (SLSN9)
  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, cilium basal body.
  • 蛋白家族：
    TRAF3IP1 family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 17861

    OMIM: 607380

    KEGG: hsa:26146

    STRING: 9606.ENSP00000362424

    UniGene: Hs.631898