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  4. Recombinant Human Transcription factor GATA-5 (GATA5)

Recombinant Human Transcription factor GATA-5 (GATA5)

  • 中文名称：
    人GATA5重组蛋白
  • 货号：
    CSB-YP883616HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人GATA5重组蛋白
  • 货号：
    CSB-EP883616HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人GATA5重组蛋白
  • 货号：
    CSB-EP883616HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人GATA5重组蛋白
  • 货号：
    CSB-BP883616HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人GATA5重组蛋白
  • 货号：
    CSB-MP883616HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    GATA5
  • Uniprot No.：
  • 别名：
    GATA binding protein 5; GATA-binding factor 5; GATA5; GATA5_HUMAN; Transcription factor GATA-5
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-397
  • 氨基酸序列
    MYQSLALAAS PRQAAYADSG SFLHAPGAGS PMFVPPARVP SMLSYLSGCE PSPQPPELAA RPGWAQTATA DSSAFGPGSP HPPAAHPPGA TAFPFAHSPS GPGSGGSAGG RDGSAYQGAL LPREQFAAPL GRPVGTSYSA TYPAYVSPDV AQSWTAGPFD GSVLHGLPGR RPTFVSDFLE EFPGEGRECV NCGALSTPLW RRDGTGHYLC NACGLYHKMN GVNRPLVRPQ KRLSSSRRAG LCCTNCHTTN TTLWRRNSEG EPVCNACGLY MKLHGVPRPL AMKKESIQTR KRKPKTIAKA RGSSGSTRNA SASPSAVAST DSSAATSKAK PSLASPVCPG PSMAPQASGQ EDDSLAPGHL EFKFEPEDFA FPSTAPSPQA GLRGALRQEA WCALALA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor required during cardiovascular development. Plays an important role in the transcriptional program(s) that underlies smooth muscle cell diversity. Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer.
  • 基因功能参考文献：
    1. findings show that GATA5 mutations, in addition to heart diseases, can result in congenital abnormalities of the female genitourinary tract in humans PMID: 28180938
    2. A multivariate regression model revealed that the effects of both the promoter methylation and the exonic SNPs in GATA5 were independent.This interaction between GATA5 variants and GATA5 promoter methylation indicates that the association of either factor with gastric disease progression is modified by the other PMID: 27225266
    3. These results suggest that the induction of GATA-6 dysfunction may be more effective for chemotherapy for colorectal cancer, although the mechanism underlying the synergistic effect of 5-FU and anisomycin remains unknown. PMID: 27404124
    4. The Correlation between GATA5, WT1 and PAX5 methylation and clinical/histological parameters is suggestive of applicability of these markers in non-invasive (epi)genetic testing in hepatocellular carcinoma (HCC). PMID: 27171388
    5. we identified gene promoter methylation signatures (WT1, MSH6, GATA5 and PAX5) that are strongly correlated to, and can have a predictive value for the clinical outcome of oral squamous cell carcinoma patients PMID: 27491556
    6. Evidence supporting a genetic basis includes the autosomal dominance of Bicuspid aortic valve inheritance patterns, and the identification of mutations in GATA binding protein 5 transcription factor. PMID: 26766164
    7. Transcriptomic analysis of human microvascular endothelial cells with GATA5 knockdown reveals that GATA5 affects several genes and pathways critical for endothelial function. PMID: 26617239
    8. This study firstly links GATA5 mutation to DCM, which provides novel insight into the molecular mechanisms of DCM, suggesting a potential molecular target for the prenatal prophylaxis and allele-specific treatment of DCM. PMID: 25543888
    9. Promoter hypermethylation is an important mechanism of the transcriptional inactivation of GATA5 in invasive ductal breast carcinoma. PMID: 25148870
    10. A combination of GATA5 and SFRP2 methylation could be promising as a marker for the detection and diagnosis of colorectal cancers and adenomas. PMID: 25759530
    11. A new potentially pathogenic variant in GATA5 contributes to the development of bicuspid aortic valve syndrome. PMID: 25449525
    12. DSVs in the GATA5 gene promoter may increase the susceptibility to the development of VSD as a risk factor. PMID: 25515806
    13. Rare sequence variants, p.Gln3Arg and p.Leu233Pro, in GATA5 are associated with human bicuspid aortic valve. PMID: 24796370
    14. study provides genetic evidence on the association of GATA5 loss-of-function mutations with enhanced susceptibility to bicuspid aortic valve (BAV), providing novel insight into the molecular mechanism involved in human BAV PMID: 24638895
    15. Results of this study showed an association of somatic GATA5 mutations with TOF, providing further insight into the underlying molecular mechanism of TOF. PMID: 24573614
    16. Epigenetic alterations in GATA family members may be associated with aggressive tumor phenotypes in renal cell cancer PMID: 24549248
    17. Reduced GATA5 mRNA levels are associated with a poor clinical outcome, indicating a possible role of GATA5 for the development of aggressive clear cell renal cell carcinoma. PMID: 24533449
    18. GATA5, possibly through upregulation of eNOS, plays a role in the development of aortic dilatation in patients with unicuspid and bicuspid aortic valves. PMID: 24766859
    19. GATA5 mutations were associated with congenital heart disease. PMID: 23031282
    20. The findings expand the spectrum of GATA5 mutations linked to atrial fibrillation and provide novel insights into the molecular mechanism involved in the pathogenesis of atrial fibrillation PMID: 23295592
    21. GATA5 protein mutataion is reposnsible for congenital ventriculoseptal defect. PMID: 22961344
    22. In the present study, two novel heterozygous mutations of GATA5, p.R187G and p.H207R, were identified in 2 families with TOF. In each family, the mutant allele was present in all the affected family members PMID: 23289003
    23. the prevalence and spectrum of GATA5 mutations in patients with familial atrial fibrillation PMID: 22483626
    24. A novel heterozygous GATA5 loss-of-function mutation of p.W200G identified in a family with lone atrial fibrillation is reported. PMID: 23175127
    25. Rare non-synonymous variations in the functionally important GATA5 transcriptional activation domains may be important in the pathogenesis of BAV disease in humans. PMID: 22641149
    26. USF1 transactivates GATA5 expression by binding to the E-box in its promoter PMID: 22625849
    27. Two new epigenetic subgroups of gastroesophageal adenocarcinomas were identified that differ to some extent in their survival rates, risk factors of exposure, and GATA5 DNA methylation. PMID: 22028801
    28. Epigenetic inactivation of GATA-5 by methylation of CpG islands is an early frequent event during gastric carcinogenesis and is significantly correlated with H. pylori infection. PMID: 20222162
    29. demonstrate that GATA-5 and HNF-1alpha physically associate both in vivo and in vitro and that this interaction is necessary for cooperative activation of the lactase-phlorizin hydrolase promoter PMID: 12011060
    30. in colorectal cancer and gastric cancer promoter hypermethylation and transcriptional silencing are frequent for GATA-4 and -5 PMID: 14612389
    31. Hypermethylation of the GATA5 is associated with lung cancer PMID: 15585625
    32. Methylation of GATA-5 was associated with ovarian carcinogenesis PMID: 16337738
    33. Frequent silencing of GATA-4 and GATA-5 in human esophageal neoplasia is associated with gene promoter hypermethylation. PMID: 16823849
    34. While hypermethylation of GATA-5 seems to be a universal feature among human tumors, infrequent methylation of GATA-4, and its corresponding overexpression, appears unique to pancreatic cancer from other tumor types reported thus far. PMID: 17912029
    35. Methylation of GATA4/5 is a common and specific event in colorectal carcinomas, and GATA4/5 exhibit tumor suppressive effects in colorectal cancer cells in vitro. GATA4 methylation in fecal DNA may be of interest for colorectal cancer detection. PMID: 19509152

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  • 相关疾病：
    Tetralogy of Fallot (TOF)
  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 15802

    OMIM: 187500

    KEGG: hsa:140628

    STRING: 9606.ENSP00000252997

    UniGene: Hs.352250