Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Human Transcription factor HES-4 (HES4)

Recombinant Human Transcription factor HES-4 (HES4)

  • 中文名称：
    人HES4重组蛋白
  • 货号：
    CSB-YP884518HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人HES4重组蛋白
  • 货号：
    CSB-EP884518HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人HES4重组蛋白
  • 货号：
    CSB-EP884518HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人HES4重组蛋白
  • 货号：
    CSB-BP884518HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人HES4重组蛋白
  • 货号：
    CSB-MP884518HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    HES4
  • Uniprot No.：
  • 别名：
    HES4; BHLHB42; Transcription factor HES-4; hHES4; Class B basic helix-loop-helix protein 42; bHLHb42; Hairy and enhancer of split 4; bHLH factor Hes4
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-221
  • 氨基酸序列
    MAADTPGKPS ASPMAGAPAS ASRTPDKPRS AAEHRKSSKP VMEKRRRARI NESLAQLKTL ILDALRKESS RHSKLEKADI LEMTVRHLRS LRRVQVTAAL SADPAVLGKY RAGFHECLAE VNRFLAGCEG VPADVRSRLL GHLAACLRQL GPSRRPASLS PAAPAEAPAP EVYAGRPLLP SLGGPFPLLA PPLLPGLTRA LPAAPRAGPQ GPGGPWRPWL R
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional repressor. Binds DNA on N-box motifs: 5'-CACNAG-3'.
  • 基因功能参考文献：
    1. Hes4 overexpression promotes a more aggressive tumor phenotype by preventing osteoblastic differentiation of osteosarcoma cells. Hes4 expression may allow for the stratification of patients into good or poor responders to chemotherapy at diagnosis. PMID: 27786411
    2. Overexpression and knockdown studies demonstrated that Hes4 promotes osteogenesis resulting in an increase in Runx2, osteocalcin, osteopontin, and bone sialoprotein expression in BMSC. PMID: 25579220
    3. Epigenetic dysregulation of HES4 could play a critical role in modifying Huntington's disease pathogenesis and severity. PMID: 25480889
  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 24149

    OMIM: 608060

    KEGG: hsa:57801

    UniGene: Hs.154029