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  4. Recombinant Human Transcription factor SOX-7 (SOX7)

Recombinant Human Transcription factor SOX-7 (SOX7)

  • 中文名称：
    人SOX7重组蛋白
  • 货号：
    CSB-YP866278HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SOX7重组蛋白
  • 货号：
    CSB-EP866278HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人SOX7重组蛋白
  • 货号：
    CSB-EP866278HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SOX7重组蛋白
  • 货号：
    CSB-BP866278HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人SOX7重组蛋白
  • 货号：
    CSB-MP866278HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SOX7
  • Uniprot No.：
  • 别名：
    MGC10895; SOX 7; SOX 7 transcription factor; sox7; SOX7 transcription factor; SOX7_HUMAN; SRY (sex determining region Y) box 7; SRY box 7; SRY sex determining region Y box 7; Transcription factor SOX 7; Transcription factor Sox-7; Transcription factor SOX7
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-388
  • 氨基酸序列
    MASLLGAYPW PEGLECPALD AELSDGQSPP AVPRPPGDKG SESRIRRPMN AFMVWAKDER KRLAVQNPDL HNAELSKMLG KSWKALTLSQ KRPYVDEAER LRLQHMQDYP NYKYRPRRKK QAKRLCKRVD PGFLLSSLSR DQNALPEKRS GSRGALGEKE DRGEYSPGTA LPSLRGCYHE GPAGGGGGGT PSSVDTYPYG LPTPPEMSPL DVLEPEQTFF SSPCQEEHGH PRRIPHLPGH PYSPEYAPSP LHCSHPLGSL ALGQSPGVSM MSPVPGCPPS PAYYSPATYH PLHSNLQAHL GQLSPPPEHP GFDALDQLSQ VELLGDMDRN EFDQYLNTPG HPDSATGAMA LSGHVPVSQV TPTGPTETSL ISVLADATAT YYNSYSVS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors. May be required for the survival of both hematopoietic and endothelial precursors during specification. Competes with GATA4 for binding and activation of the FGF3 promoter. Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5'-AACAAT-3'.
  • 基因功能参考文献：
    1. These results provide the first clue that miR-24-3p could play a role as an oncomiR in Lung cancer by regulating SOX7. PMID: 29231262
    2. we have identified an array of potential target genes of SOX7 and examined four of them for their roles in SOX7-mediated tumor suppression. We found that SOX7 could both activate and repress its target genes; and achieve its antiproliferative function through regulating multiple genes simultaneously. PMID: 29757932
    3. SOX7 transcription factor mediates PDGF-BB-induced IL-33 expression. PMID: 27150562
    4. Mechanistically, SOX7 was confirmed to be the downstream target of miR-616 in NSCLC cells. Forced expression of SOX7 prevented the promoting effects of miR-616 overexpression on the proliferation and metastasis of NSCLC cells, while knockdown of SOX7 reversed the inhibitory effects of miR-616 knockdown on the proliferation and metastasis of NSCLC cells. PMID: 28765960
    5. miR-9 was up-regulated and SOX7 was down-regulated in human non-small-cell lung cancer tissues and cell lines. PMID: 28266181
    6. The results indicate that SOX7 may inhibit the progression of liver carcinoma and that SOX7 downregulation may accurately predict poor prognosis in liver carcinoma patients. PMID: 28586005
    7. Consistent with bioinformatics predictions, SOX7 was correlated positively with AXIN2 and negatively with beta-catenin, suggesting that SOX7 and AXIN2 might play important roles as co-regulators through the Wnt-beta-catenin pathway in the breast tissue to affect the carcinogenesis process. PMID: 27188720
    8. SOX7 inhibits oncogenic beta-catenin-mediated transcription by disrupting the beta-catenin/BCL9 interaction. PMID: 29271667
    9. Overexpression of miR-935 inhibited SOX7 expression. PMID: 27697092
    10. The results suggest that miR-664 functions as an oncogene miRNA and has an important role in promoting human osteosarcoma cell invasion and migration by suppressing SOX7 expression. PMID: 26515813
    11. miR-595 played a critical role in carcinogenesis by suppression of SOX7. PMID: 27133048
    12. Aberrant methylation of the promoter regions of the SOX7 gene in patients with acute myeloid leukemias. PMID: 27459612
    13. miR-935 contributed to cell proliferation of gastric cancer through targeting SOX7. PMID: 27044823
    14. the HMG-box is a key domain of SOX7 for negatively regulating the Wnt/beta-catenin signaling pathway when functioning as a tumor suppressor in a glioma. PMID: 26944317
    15. The results provided unequivocal evidence for a novel tumor suppressor role of SOX7 in acute myeloid leukemia PMID: 25940713
    16. SOX7 plays an important inhibitory role in hepatocarcinogenesis, and might be a novel target for hepatocellular carcinoma therapy. PMID: 24816720
    17. Ectopic expression of miR-492 led to downregulation of SOX7 protein. PMID: 25407488
    18. Low SOX7 expression is associated with hepatocellular carcinoma. PMID: 25073511
    19. The expression of SOX7 correlates with tumor progression as a tumor suppressor, possibly through the Wnt/beta-catenin signaling pathway in ovarian cancers, suggesting that SOX7 may be a promising prognostic marker. PMID: 25297608
    20. Decreased expression of Sox7 correlates with the upregulation of the Wnt/beta-catenin signaling pathway and the poor survival of gastric cancer patients. PMID: 24788044
    21. miR-184 represents a potential onco-miR and plays an important role in HCC progression by suppressing SOX7 expression PMID: 24558429
    22. SOX7 acts as a tumor suppressor in breast cancer. PMID: 24012678
    23. SOX7 is a novel tumor suppressor gene silenced in the majority of NSCLC samples. PMID: 23557216
    24. Sox7 is a negative regulator of Wnt/beta-catenin signaling pathway through impeding the transcriptional machinery of beta-catenin/TCF/LEF-1 transcriptional complex, and the loss of expression may be involved in the pathogenesis of endometrial cancer. PMID: 23295859
    25. Association of SOX7 protein expression with clinical outcomes was evaluated. SOX7 mRNA expression was significantly down-regulated in lung adenocarcinoma compared with matched adjacent normal tissues. PMID: 22777918
    26. The methylation of the CpG island of the SOX7 gene can be used as a predictive factor for the development and prognosis of myelodysplastic syndrome patients. PMID: 22706399
    27. Data show that SOX7 is upregulated by aspirin and is involved in aspirin-mediated growth inhibition of human colorectal cancer SW480 cells. PMID: 22171135
    28. stable endoderm progenitors can be established from human ES cells by constitutive expression of SOX7 producing extraembryonic endoderm progenitors PMID: 18682240
    29. Sox7 is a tumor suppressor that functions as an independent checkpoint for beta-catenin transcriptional activity. Inactivation of Sox7 could promote the development of a majority of colorectal tumors and approximately half of prostate tumors. PMID: 18819930
    30. stable expression induces a stable expandable extra embryonic endoderm phenotype in hESCs PMID: 18940723
    31. SOX7, down-regulated in colorectal cancer, induces apoptosis and inhibits proliferation of colorectal cancer cells. PMID: 19108950
    32. gene expression, chromosome mapping, transactivation, interference with Wnt signaling PMID: 11691915

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 组织特异性：
    Widely expressed in adult and fetal tissues. Present both in mesenchymal and epithelial cells in some adult tissues, including colon. Tends to be down-regulated in prostate adenocarcinomas and colorectal tumors due to promoter hypermethylation.
  • 数据库链接：

    HGNC: 18196

    OMIM: 612202

    KEGG: hsa:83595

    STRING: 9606.ENSP00000301921

    UniGene: Hs.709543