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  4. Recombinant Human Uncharacterized protein C10orf46 (C10orf46)

Recombinant Human Uncharacterized protein C10orf46 (C10orf46)

  • 中文名称：
    Recombinant Human Uncharacterized protein C10orf46(C10orf46),Yeast
  • 货号：
    CSB-YP803151HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Uncharacterized protein C10orf46(C10orf46),Yeast
  • 货号：
    CSB-EP803151HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Uncharacterized protein C10orf46(C10orf46),Yeast
  • 货号：
    CSB-EP803151HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Uncharacterized protein C10orf46(C10orf46),Yeast
  • 货号：
    CSB-BP803151HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Uncharacterized protein C10orf46(C10orf46),Yeast
  • 货号：
    CSB-MP803151HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    CACUL1
  • Uniprot No.：
  • 别名：
    CACUL1; C10orf46; CAC1CDK2-associated and cullin domain-containing protein 1; Cdk-associated cullin1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-369
  • 氨基酸序列
    MEESMEEEEG GSYEAMMDDQ NHNNWEAAVD GFRQPLPPPP PPSSIPAPAR EPPGGQLLAV PAVSVDRKGP KEGLPMGPQP PPEANGVIMM LKSCDAAAAV AKAAPAPTAS STININTSTS KFLMNVITIE DYKSTYWPKL DGAIDQLLTQ SPGDYIPISY EQIYSCVYKC VCQQHSEQMY SDLIKKITNH LERVSKELQA SPPDLYIERF NIALGQYMGA LQSIVPLFIY MNKFYIETKL NRDLKDDLIK LFTEHVAEKH IYSLMPLLLE AQSTPFQVTP STMANIVKGL YTLRPEWVQM APTLFSKFIP NILPPAVESE LSEYAAQDQK FQRELIQNGF TRGDQSRKRA GDELAYNSSS ACASSRGYR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition.
  • 基因功能参考文献：
    1. These data suggest that CACUL1 is a novel regulator that negatively controls p53 activity through the regulation of PML SUMOylation. PMID: 27889610
    2. Suggest that CACUL1 impairs LSD1-mediated activation of AR, thereby implicating it as a potential antitumor target in prostate cancer cells. PMID: 27085459
    3. silencing CACUL1 resulted in the same effects of miR-106a* overexpression in esophageal carcinoma cells, including suppressed esophageal carcinoma cell proliferation and blocked G1/S transition through CDK2 pathway by inhibiting cell cycle regulators. PMID: 26314198
    4. H. pylori-triggered CACUL1 production occurred in an activating protein 1-dependent manner and regulated matrix metalloproteinase 9 and Slug expression to affect the invasion and metastasis of tumor cells. PMID: 24004834
    5. CAC1 promoted the proliferation of human lung cancer A549 cells with activation of ERK1/2 signaling pathways. PMID: 23806693
    6. High CAC1 expression is associated with cisplatin resistance in gastric cancer. PMID: 23311997
    7. miR-199a-5p can regulate CAC1 and function as a tumor suppressor in colorectal cancer. PMID: 22903020
    8. CAC1 is an important factor for the protection of cells against amyloid beta toxicity and oxidative stress in Alzheimer's disease. PMID: 22415352
    9. CAC1 is a novel corepressor of RARalpha that cooperates with HDACs and is involved in the regulation of RA-induced cellular differentiation. PMID: 22982681
    10. Data suggest that CAC1, in association with LSD1 (lysine-specific histone demethylase 1), functions as a corepressor of estrogen receptor alpha and may be involved in drug resistance in breast cancer. PMID: 23178685
    11. CAC1 is a novel cell cycle associated protein capable of promoting cell proliferation. PMID: 19829063

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  • 蛋白家族：
    Cullin family
  • 组织特异性：
    Ubiquitously expressed with highest expression in the mammary gland and large intestine. Highly expressed in cancer tissues and cancer cell lines. During cell cycle progression expression is high in G1/S, low in the middle of S phase, and increases again
  • 数据库链接：

    HGNC: 23727

    KEGG: hsa:143384

    STRING: 9606.ENSP00000358147

    UniGene: Hs.420024