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  4. Recombinant Human WD repeat-containing protein 91 (WDR91)

Recombinant Human WD repeat-containing protein 91 (WDR91)

  • 货号：
    CSB-YP026077HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP026077HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP026077HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP026077HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP026077HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    WDR91
  • Uniprot No.：
  • 别名：
    HSPC049; WD repeat containing protein 91; WD repeat domain 91; WD repeat-containing protein 91; WDR 91; WDR91; WDR91_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-747
  • 氨基酸序列
    MAEAVERTDE LVREYLLFRG FTHTLRQLDA EIKADKEKGF RVDKIVDQLQ QLMQVYDLAA LRDYWSYLER RLFSRLEDIY RPTIHKLKTS LFRFYLVYTI QTNRNDKAQE FFAKQATELQ NQAEWKDWFV LPFLPSPDTN PTFATYFSRQ WADTFIVSLH NFLSVLFQCM PVPVILNFDA ECQRTNQVQE ENEVLRQKLF ALQAEIHRLK KEEQQPEEEE ALVQHKLPPY VSNMDRLGDS ELAMVCSQRN ASLSQSPRVG FLSSLLPQSK KSPSRLSPAQ GPPQPQSSAK KESFGGQGTK GKDPTSGAKD GKSLLSGLAT GESGWSQHRQ RRLQDHGKER KELFSTTTSQ CAEKKPEASG PEAEPCPELH TEPVEPLTRA SSAGPEGGGV RPEQPFIVLG QEEYGEHHSS IMHCRVDCSG RRVASLDVDG VIKVWSFNPI MQTKASSISK SPLLSLEWAT KRDRLLLLGS GVGTVRLYDT EAKKNLCEIN INDNMPRILS LACSPNGASF VCSAAAPSLT SQVDFSAPDI GSKGMNQVPG RLLLWDTKTM KQQLQFSLDP EPIAINCTAF NHNGNLLVTG AADGVIRLFD MQQHECAMSW RAHYGEVYSV EFSYDENTVY SIGEDGKFIQ WNIHKSGLKV SEYSLPSDAT GPFVLSGYSG YKQVQVPRGR LFAFDSEGNY MLTCSATGGV IYKLGGDEKV LESCLSLGGH RAPVVTVDWS TAMDCGTCLT ASMDGKIKLT TLLAHKA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport. It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome. May play a role in meiosis.
  • 基因功能参考文献：
    1. suggest a role for the WDR81-WDR91 complex in the fusion of endolysosomal compartments and the absence of WDR81 leads to impaired receptor trafficking and degradation PMID: 27126989
    2. WDR91 serves as a Rab7 effector that is essential for neuronal development by facilitating endosome conversion in the endosome-lysosome pathway. PMID: 28860274
  • 亚细胞定位：
    Early endosome membrane; Peripheral membrane protein. Late endosome membrane.
  • 蛋白家族：
    WD repeat WDR91 family
  • 数据库链接：

    HGNC: 24997

    KEGG: hsa:29062

    STRING: 9606.ENSP00000346466

    UniGene: Hs.459858