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  4. Recombinant Human Zinc finger protein with KRAB and SCAN domains 4 (ZKSCAN4)

Recombinant Human Zinc finger protein with KRAB and SCAN domains 4 (ZKSCAN4)

  • 中文名称：
    人ZKSCAN4重组蛋白
  • 货号：
    CSB-YP836168HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人ZKSCAN4重组蛋白
  • 货号：
    CSB-EP836168HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人ZKSCAN4重组蛋白
  • 货号：
    CSB-EP836168HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人ZKSCAN4重组蛋白
  • 货号：
    CSB-BP836168HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人ZKSCAN4重组蛋白
  • 货号：
    CSB-MP836168HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ZKSCAN4
  • Uniprot No.：
  • 别名：
    FLJ32136; P1P373C6; p373c6.1 (novel C2H2 type zinc finger protein); P373c6.1; Zinc finger protein 307; Zinc finger protein 427; Zinc finger protein with KRAB and SCAN domains 4; Zinc finger with KRAB and SCAN domains 4; ZKSC4_HUMAN; ZKSCAN4; ZNF427
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-545
  • 氨基酸序列
    MAREPRKNAA LDAQSAEDQT GLLTVKVEKE EASALTAEVR APCSPARGPE RSRQRFRGFR YPEAAGPREA LSRLRELCGQ WLQPEMHSKE QILELLVLEQ FLTILPGNLQ SWVREQHPES GEEVVVLLEY LERQLDEPAP QVPVGDQGQE LLCCKMALLT QTQGSQSSQC QPMKALFKHE SLGSQPLHDR VLQVPGLAQG GCCREDAMVA SRLTPGSQGL LKMEDVALTL TPGWTQLDSS QVNLYRDEKQ ENHSSLVSLG GEIQTKSRDL PPVKKLPEKE HGKICHLRED IAQIPTHAEA GEQEGRLQRK QKNAIGSRRH YCHECGKSFA QSSGLTKHRR IHTGEKPYEC EDCGKTFIGS SALVIHQRVH TGEKPYECEE CGKVFSHSSN LIKHQRTHTG EKPYECDDCG KTFSQSCSLL EHHKIHTGEK PYQCNMCGKA FRRNSHLLRH QRIHGDKNVQ NPEHGESWES QGRTESQWEN TEAPVSYKCN ECERSFTRNR SLIEHQKIHT GEKPYQCDTC GKGFTRTSYL VQHQRSHVGK KTLSQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May be involved in the transcriptional activation of MDM2 and EP300 genes.
  • 基因功能参考文献：
    1. our results indicate that ZNF307 may serve as a tumor suppressor and inhibits cell proliferation of hepatocellular carcinoma via inducing apoptosis PMID: 28765950
    2. ZNF307 ameliorates pressure overload-induced cardiac hypertrophy by inhibiting the activity of NF-kappaB-signaling pathway PMID: 28223477
    3. ZNF307 might suppress p53-p21 pathway through activating MDM2 and EP300 expression and inducing p53 degradation PMID: 17910948
    4. The SCAN- and KRAB-domain-containing zinc finger protein 307 (ZKSCAN4) was co-precipitated with the receptor when both proteins were overexpressed in HEK293 cells. PMID: 19008334
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Krueppel C2H2-type zinc-finger protein family
  • 组织特异性：
    Expressed in adult heart, brain, placenta, lung and kidney, but not in adult liver and skeletal muscle. In 17-day old embryo, detected in liver, skeletal muscle, brain, heart and small intestine.
  • 数据库链接：

    HGNC: 13854

    OMIM: 611643

    KEGG: hsa:387032

    STRING: 9606.ENSP00000366509

    UniGene: Hs.44720