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  4. Recombinant Human Zona pellucida-binding protein 2 (ZPBP2)

Recombinant Human Zona pellucida-binding protein 2 (ZPBP2)

  • 中文名称：
    人ZPBP2重组蛋白
  • 货号：
    CSB-YP751060HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人ZPBP2重组蛋白
  • 货号：
    CSB-EP751060HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人ZPBP2重组蛋白
  • 货号：
    CSB-EP751060HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人ZPBP2重组蛋白
  • 货号：
    CSB-BP751060HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人ZPBP2重组蛋白
  • 货号：
    CSB-MP751060HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ZPBP2
  • Uniprot No.：
  • 别名：
    MGC41930; Zona pellucida binding protein 2; Zona pellucida binding protein like; Zona pellucida-binding protein 2; ZPBP-like protein; Zpbp2; ZPBP2_HUMAN; ZPBPL
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    21-338
  • 氨基酸序列
    PRFTLFNKKG FIYGKTGQPD KIYVELHQNS PVLICMDFKL SKKEIVDPTY LWIGPNEKTL TGNNRINITE TGQLMVKDFL EPLSGLYTCT LSYKTVKAET QEEKTVKKRY DFMVFAYREP DYSYQMAVRF TTRSCIGRYN DVFFRVLKKI LDSLISDLSC HVIEPSYKCH SVEIPEHGLI HELFIAFQVN PFAPGWKGAC NGSVDCEDTT NHNILQARDR IEDFFRSQAY IFYHNFNKTL PAMHFVDHSL QVVRLDSCRP GFGKNERLHS NCASCCVVCS PATFSPDVNV TCQTCVSVLT YGAKSCPQTS NKNQQYED
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Is implicated in sperm-oocyte interaction during fertilization.
  • 基因功能参考文献：
    1. The local genotype influences methylation levels at SLC22A5 and ZPBP2 promoters independently of the asthma status. Further studies are necessary to confirm the relationship between GSDMA-ZPBP2 and SLC22A5 methylation and asthma in females and males separately. PMID: 26671913
    2. The allele T of rs10852936 surrounding the IKZF3-ZPBP2 locus confers risk for early-onset psoriasis. PMID: 25620289
    3. allele-specific transcriptional regulation of genes in the asthma-associated chromosomal region 17q12-q21; rs4795397 influences activity of ZPBP2 promoter in an allele-dependent fashion and leads to nucleosome repositioning on the asthma-associated allele; methylation of exon 1 of ZPBP2 masks the genetic effect on ZPBP2 promoter; ORMDL3 promoter is unmethylated PMID: 22271045
    4. Data show that loss of zona pellucida binding proteins 1 and 2 in the acrosomal matrix disrupts acrosome biogenesis and sperm morphogenesis. PMID: 17664285
  • 亚细胞定位：
    Cytoplasmic vesicle, secretory vesicle, acrosome. Secreted.
  • 蛋白家族：
    Zona pellucida-binding protein Sp38 family
  • 组织特异性：
    Expressed specifically in testis.
  • 数据库链接：

    HGNC: 20678

    OMIM: 608499

    KEGG: hsa:124626

    STRING: 9606.ENSP00000335384

    UniGene: Hs.367245