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Recombinant MANF/CDNF-like protein (Y54G2A.23)

  • 中文名称：
    秀丽隐杆线虫Y54G2A.23重组蛋白
  • 货号：
    CSB-YP878800CXY
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    秀丽隐杆线虫Y54G2A.23重组蛋白
  • 货号：
    CSB-EP878800CXY
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    秀丽隐杆线虫Y54G2A.23重组蛋白
  • 货号：
    CSB-EP878800CXY-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    秀丽隐杆线虫Y54G2A.23重组蛋白
  • 货号：
    CSB-BP878800CXY
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    秀丽隐杆线虫Y54G2A.23重组蛋白
  • 货号：
    CSB-MP878800CXY
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Y54G2A.23
  • Uniprot No.：
  • 别名：
    manf-1; Y54G2A.23; Mesencephalic astrocyte-derived neurotrophic factor homolog; ARMET-like protein; MANF/CDNF-like protein
  • 种属：
    Caenorhabditis elegans
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    18-168
  • 氨基酸序列
    AAP QCEVCKKVLD DVMAKVPAGD KSKPDAIGKV IREHCETTRN KENKFCFYIG ALPESATSIM NEVTKPLSWS MPTEKVCLEK LKGKDAQICE LKYDKPLDWK TIDLKKMRVK ELKNILGEWG EVCKGCTEKA ELIKRIEELK PKYVKEEL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Inhibits endoplasmic reticulum (ER) stress response. Retained in the ER under normal conditions and is up-regulated and secreted by the ER in response to ER stress and hypoxia. Following secretion by the ER, directly binds to 3-O-sulfogalactosylceramide, a lipid sulfatide in the outer cell membrane of target cells. Sulfatide binding promotes its cellular uptake by endocytosis, and is required for its role in alleviating ER stress under ER stress conditions. Has a neuroprotective role, ensuring survival of dopaminergic neurons during normal growth.
  • 基因功能参考文献：
    1. Sulfatide binding promotes cellular MANF uptake and cytoprotection from hypoxia-induced cell death. PMID: 29497057
  • 亚细胞定位：
    Secreted. Endoplasmic reticulum lumen.
  • 蛋白家族：
    ARMET family
  • 组织特异性：
    Expressed in the intestine, spermatheca and nervous system. Expressed in the hypoderm. Expressed in structures of the excretory system. Not expressed in the male gonad.
  • 数据库链接：

    KEGG: cel:CELE_Y54G2A.23

    STRING: 6239.Y54G2A.23.2

    UniGene: Cel.20205