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  4. Recombinant Macrovipera lebetina Zinc metalloproteinase/disintegrin

Recombinant Macrovipera lebetina Zinc metalloproteinase/disintegrin

  • 中文名称：
    Recombinant Macrovipera lebetina Zinc metalloproteinase/disintegrin,Yeast
  • 货号：
    CSB-YP850673MPJ
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Macrovipera lebetina Zinc metalloproteinase/disintegrin,Yeast
  • 货号：
    CSB-EP850673MPJ
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Macrovipera lebetina Zinc metalloproteinase/disintegrin,Yeast
  • 货号：
    CSB-EP850673MPJ-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Macrovipera lebetina Zinc metalloproteinase/disintegrin,Yeast
  • 货号：
    CSB-BP850673MPJ
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Macrovipera lebetina Zinc metalloproteinase/disintegrin,Yeast
  • 货号：
    CSB-MP850673MPJ
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    N/A
  • Uniprot No.：
  • 别名：
    ; Zinc metalloproteinase/disintegrin [Cleaved into: Snake venom metalloproteinase lebetase; SVMP; EC 3.4.24.-; Fibrinolytic protease; Le-3; Le3; Lebetase II; Lebetase-2); Disintegrin VLE5A]
  • 种属：
    Macrovipera lebetina (Levantine viper) (Vipera lebetina)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    195-397
  • 氨基酸序列
    QQRFEP RYIELVIVAD HAMVTKYNGD LAAITTWVHQ LVNNINGFYR DLNVHITLSA VEVWTNGDLI NVQPAASVTL NLFGEWRERD LLNRRMHDHA QLLTGIDLDD NIIGLAYDDS MCDPRYSVGI VQDHSAIIRL VAVTMAHELG HNLGMNHDGD QCNCGANGCV MSVVLIEQRS YQFSDCSKNK YQTYLTNRNP QCILNQP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    fibrinolytic and fibrinogenolytic metalloproteinase that hydrolyzes the Aalpha-chain and more slowly the Bbeta-chain of fibrin and fibrinogen. Its fibrinolytic activity is direct, without any plasminogen activation. Also hydrolyzes casein and B-chain of oxidized insulin. Inhibits ADP-induced and collagen-induced platelet aggregation. Shows low hemorrhagic activity. Cleaves the plasma proteinase inhibitors alpha(2)-macroglobulin (A2M) and pregnancy zone protein (PZP), and is inhibited by them. The metalloprotease has no strict P1-P1' specificity requirement. Hydrolysis at sites with a Pro residue at P1 is observed with bradykinin, substance P, PZP and alpha chain fibrinogen (FGA).; poor inhibitor of platelet aggregation. The disintegrin inhibits the adhesion of the alpha-4/beta-1 (ITGA4/ITGB1) integrin to VCAM-1. Inhibition on alpha-2b/beta-3 (ITGA2B/ITGB3) is low.
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Venom metalloproteinase (M12B) family, P-II subfamily, P-IIe sub-subfamily
  • 组织特异性：
    Expressed by the venom gland.