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  4. Recombinant Mouse Alpha-hemoglobin-stabilizing protein (Ahsp)

Recombinant Mouse Alpha-hemoglobin-stabilizing protein (Ahsp)

  • 中文名称：
    Recombinant Mouse Alpha-hemoglobin-stabilizing protein(Ahsp),Yeast
  • 货号：
    CSB-YP875156MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Alpha-hemoglobin-stabilizing protein(Ahsp),Yeast
  • 货号：
    CSB-EP875156MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Alpha-hemoglobin-stabilizing protein(Ahsp),Yeast
  • 货号：
    CSB-BP875156MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Alpha-hemoglobin-stabilizing protein(Ahsp),Yeast
  • 货号：
    CSB-MP875156MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ahsp
  • Uniprot No.：
  • 别名：
    Ahsp; Edrf; ErafAlpha-hemoglobin-stabilizing protein; Erythroid differentiation-related factor; Erythroid-associated factor
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-102
  • 氨基酸序列
    MAPFQSNKDL ISTGIKEFNV LLDQQVFDDP LISEEDMVIV VHDWVNLYTN YYKKLVHGEQ EEQDRAMTEF QQELSTLGSQ FLAKYRTFLK SKEPPSNTLP SS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation.
  • 基因功能参考文献：
    1. role of alpha-hemoglobin stabilizing protein in hemoglobin assembly PMID: 22287545
    2. Endogenous AHSP is not limiting for alpha-globin detoxification in beta-thalassemic mice. PMID: 20815047
    3. An abundant erythroid protein that stabilizes free alpha-haemoglobin. PMID: 12066189
    4. activin A does not appear to affect the exocrine or endocrine components of the pancreas, but promotes differentiation of pancreatic tissue into intestine via a Shh-dependent mechanism PMID: 15054113
    5. Loss of AHSP impairs erythropoiesis and exacerbates beta-thalassemia. PMID: 15545996
    6. These results support the hypothesis that EKLF acts as a transcription factor and a chromatin modulator for the AHSP and beta-globin genes and indicate that EKLF may play similar roles for other erythroid genes. PMID: 16705186
    7. developmental stage- and differentiation state-specific regulation of the nuclear transport of EKLF might be one of the steps necessary for the switch-on of the mammalian adult beta globin gene transcription PMID: 17242208
    8. AHSP also acts as a molecular chaperone to stabilize nascent alpha-globin for hemoglobin A assembly PMID: 17607360
    9. The expression of AHSP in a subclone of murine erythroleukemia cells in relationship to prion protein on the cell surface is reported. PMID: 18828445

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    AHSP family
  • 组织特异性：
    Expressed in spleen, bone marrow, and blood, with highest levels in bone marrow.
  • 数据库链接：

    KEGG: mmu:170812

    UniGene: Mm.423023