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  4. Recombinant Mouse Ankyrin repeat domain-containing protein 23 (Ankrd23)

Recombinant Mouse Ankyrin repeat domain-containing protein 23 (Ankrd23)

  • 中文名称：
    Recombinant Mouse Ankyrin repeat domain-containing protein 23(Ankrd23),Yeast
  • 货号：
    CSB-YP800392MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Ankyrin repeat domain-containing protein 23(Ankrd23),Yeast
  • 货号：
    CSB-EP800392MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Ankyrin repeat domain-containing protein 23(Ankrd23),Yeast
  • 货号：
    CSB-EP800392MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Ankyrin repeat domain-containing protein 23(Ankrd23),Yeast
  • 货号：
    CSB-BP800392MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Ankyrin repeat domain-containing protein 23(Ankrd23),Yeast
  • 货号：
    CSB-MP800392MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ankrd23
  • Uniprot No.：
  • 别名：
    Ankrd23; DarpAnkyrin repeat domain-containing protein 23; Diabetes-related ankyrin repeat protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-306
  • 氨基酸序列
    MDFISIEQLV SGERVDRKAL EFGRGVPDPG GWPSGWTLGP QEAVAREKLK LEEEKRKKLE RFNSSRLTLD NLTDLENLVQ RRRKKRQRHK VPPREPESGA EPQPQVPLEP VGLEMFLKAA AENQEALIDK YLADGGDPNA HDKLHRTALH WACLKGHRQL VNKLLAAGAA IEVRDLLDRT PVFWACRGGH LDILKRLLNQ GAQVNAQDKI WSTPLHVAVR MGHSDCLEHL IECGAHINAQ DKEGDTALHE AVRYGHHKAT KLLLLYGAKL GVKNVASQTP VQLARDWQRG IRDALQAHVG HPRTRC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May be involved in the energy metabolism. Could be a molecular link between myofibrillar stretch-induced signaling pathways and muscle gene expression.
  • 基因功能参考文献：
    1. Ankrd23(-/-) mice exhibit limited ability to form collateral arteries following femoral artery occlusion compared to WT mice. Further research will be required to determine whether Ankrd23 plays an important role in mechanically induced vascular remodeling of the arterial tree in skeletal muscle. PMID: 27889934
    2. Results showed expression of myoblast differentiation marker genes were increased by interference and reduced by ANKRD23 overexpression, indicating that ANKRD23 played a negative role in the myoblast differentiation; discovered a long non-coding RNA-AK004293 which was overlapped with the 3'UTR of ANKRD23 gene. Thus, AK004293 had no significant effect on the expression of myoblast differentiation maker genes and ANKRD23. PMID: 28754631
    3. DARP regulates glucose disposal in skeletal muscle and thus modifies the glucose homeostasis by modulating AMPK activity. PMID: 26398569
    4. CARP, Ankrd2, and DARP are not essential for normal cardiac development and function at basal conditions and in response to mechanical pressure overload. PMID: 24736439
    5. investigation of potential role in energy metabolism PMID: 12456686
    6. DARP plays important structural and gene regulatory roles in skeletal muscle. PMID: 17392382
    7. Dapr is involved in the PI3K signaling cascade, potentially acting as a scaffold protein for PKB and coordinating its compartmentalization during differentiation. PMID: 19028694

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    KEGG: mmu:78321

    STRING: 10090.ENSMUSP00000061168

    UniGene: Mm.41421