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  4. Recombinant Mouse Astrocytic phosphoprotein PEA-15 (Pea15)

Recombinant Mouse Astrocytic phosphoprotein PEA-15 (Pea15)

  • 中文名称：
    小鼠Pea15重组蛋白
  • 货号：
    CSB-YP737066MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Pea15重组蛋白
  • 货号：
    CSB-EP737066MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Pea15重组蛋白
  • 货号：
    CSB-EP737066MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Pea15重组蛋白
  • 货号：
    CSB-BP737066MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Pea15重组蛋白
  • 货号：
    CSB-MP737066MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Pea15
  • Uniprot No.：
  • 别名：
    Pea15; Pea15a; Astrocytic phosphoprotein PEA-15; 15 kDa phosphoprotein enriched in astrocytes
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-130
  • 氨基酸序列
    MAEYGTLLQD LTNNITLEDL EQLKSACKED IPSEKSEEIT TGSAWFSFLE SHNKLDKDNL SYIEHIFEIS RRPDLLTMVV DYRTRVLKIS EEEELDTKLT RIPSAKKYKD IIRQPSEEEI IKLAPPPKKA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm. Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface.
  • 基因功能参考文献：
    1. Under conditions of reduced glucose, the PS1/gamma-secretase system decreases neuronal losses by suppressing miR-212 and increasing its target survival factor, PEA15. These observations have implications for mechanisms of neuronal death under conditions of reduced glucose and may provide targets for intervention in neurodegenerative disorders. PMID: 28855274
    2. the neurological and neurochemical phenotype of transgenic mice overexpressing PED/PEA-15 (tgPED), were analyzed. PMID: 27426254
    3. PEA-15 is a protective mediator in the vasculature and acts, at least in part, by inhibiting ERK1/2-dependent nuclear signaling in vascular smooth muscle cells during neointimal hyperplasia. PMID: 28893763
    4. Data suggest that PEA-15 contributes to the specification of the cytokine pattern of activated Th cells, thus highlighting a potential new target to interfere with T cell functional polarization and subsequent immune response. PMID: 26317969
    5. PED/PEA-15 overexpression is sufficient to block hydrogen peroxide-induced apoptosis in Ins-1E cells through a PLD-1 mediated mechanism PMID: 25489735
    6. Activated astrocytes are known to clear the Abeta deposited in the extracellular milieu, which is why they play a key role in regulating the progression of Alzheimer's disease (AD). PMID: 25108202
    7. Activation of peroxisome proliferator-activated receptor-gamma (PPARgamma) represses transcription of the ped/pea-15 gene. PMID: 23105093
    8. The findings revealed a novel mechanism by which PEA-15 positively regulates Ras/ERK signaling and increases the proliferation of H-Ras-transformed epithelial cells through enhanced phospholipase D1 expression and activation. PMID: 22105357
    9. PEA-15 did not differentiate and showed markedly enhanced autophagy. In these same cells, the autophagy inhibitor 3-methyladenine rescued TGF-beta1 effect on both autophagy and myogenesis, indicating that PEA-15 mediates TGF-beta1 effects in muscle. PMID: 22281705
    10. Data suggest that PED/PEA-15 may affect fibroblast motility by a mechanism, at least in part, mediated by ERK1/2. PMID: 21780113
    11. we propose that PEA-15 represents a novel point of convergence of the protein kinas C and MAPK/ERK pathways under gonadotropin releasing hormone stimulation PMID: 21436256
    12. PEA-15 regulates T-cell proliferation PMID: 20354143
    13. PEA-15 inhibits tumorigenesis in an MDA-MB-468 triple-negative breast cancer xenograft model through increased cytoplasmic localization of activated extracellular signal-regulated kinase. PMID: 20215547
    14. Normal astrocytes express PEA-15 positive astrocytes in all areas of the adult mouse brain; PEA-15 positive astrocytes represent only a subpopulation in each region, the hippocampus being the most striking example of this heterogeneity. PMID: 15207344
    15. Overexpression of PED/PEA-15 dysregulates beta-cell function and is sufficient to impair glucose tolerance in mice. PMID: 17327429
    16. PEA-15 can integrate signal transduction to provide a specific physiological outcome from activation of the multipotent extracellular signal-regulated MAP kinase pathway. PMID: 18077417
    17. disruption of the PED/PEA-15-PLD1 molecular interaction enhances insulin sensitivity in skeletal muscle cells PMID: 18541525
    18. PTEN influences Fas signaling, at least in part, by regulating PEA-15 phosphorylation and activity that, in turn, regulate the ability of Bcl-2 to suppress Fas-induced apoptosis. PMID: 19103758
    19. We suggest PEA-15 may be an essential regulator of ERK-dependent spatial learning. PMID: 19917132

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  • 亚细胞定位：
    Cytoplasm. Note=Associated with microtubules.
  • 组织特异性：
    Predominantly expressed in the brain. Low levels in some peripheral organs.
  • 数据库链接：

    KEGG: mmu:18611

    STRING: 10090.ENSMUSP00000013842

    UniGene: Mm.544