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  4. Recombinant Mouse Basic leucine zipper transcriptional factor ATF-like 3 (Batf3)

Recombinant Mouse Basic leucine zipper transcriptional factor ATF-like 3 (Batf3)

  • 中文名称：
    Recombinant Mouse Basic leucine zipper transcriptional factor ATF-like 3(Batf3),Yeast
  • 货号：
    CSB-YP863497MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Basic leucine zipper transcriptional factor ATF-like 3(Batf3),Yeast
  • 货号：
    CSB-EP863497MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Basic leucine zipper transcriptional factor ATF-like 3(Batf3),Yeast
  • 货号：
    CSB-EP863497MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Basic leucine zipper transcriptional factor ATF-like 3(Batf3),Yeast
  • 货号：
    CSB-BP863497MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Basic leucine zipper transcriptional factor ATF-like 3(Batf3),Yeast
  • 货号：
    CSB-MP863497MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Batf3
  • Uniprot No.：
  • 别名：
    Batf3Basic leucine zipper transcriptional factor ATF-like 3; B-ATF-3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-118
  • 氨基酸序列
    MSQGPPAVSV LQRSVDAPGN QPQSPKDDDR KVRRREKNRV AAQRSRKKQT QKADKLHEEH ESLEQENSVL RREISKLKEE LRHLSEVLKE HEKMCPLLLC PMNFVQLRSD PVASCLPR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    AP-1 family transcription factor that controls the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes. Required for development of CD8-alpha(+) classical dendritic cells (cDCs) and related CD103(+) dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens.
  • 基因功能参考文献：
    1. These results underscore a specific role for Batf3-dependent dendritic cells in regulating priming and expansion of effector CD8(+) T cells necessary for host resistance against acute respiratory vaccinia virus infection. PMID: 29875235
    2. Batf3 bound to the CNS1 region of the Foxp3 locus and reduced expression of the gene. Thus, Batf3 is a transcriptional suppressor of Treg differentiation. PMID: 29147008
    3. The transcription factor Batf3 inhibits the differentiation of regulatory T cells in the periphery. We found that expression of Batf3 was selectively low in Treg cells but not in effector CD4 T (Teff) cells and that ectopic expression of Batf3 caused a marked reduction in the number of Foxp3+ Treg cells. Batf3 acts as a fate-decision factor with respect to Tconv versus Tregs by restraining Treg differentiation. PMID: 29147008
    4. in contrast to adult mice, Batf3-dependent dendritic cells were absolutely required for generating rotavirus-specific CD8+ T-cell responses in neonates PMID: 27600308
    5. Batf3(-/-) mice remained competent for skin graft rejection and delayed hypersensitivity, and retained a CD8(+) dendritic cell population. PMID: 27897162
    6. Lack of Batf3/CD103(+) dendritic cells within the tumor microenvironment dominantly resists the effector phase of an anti-tumor T cell response, contributing to immune escape. PMID: 28486109
    7. study reports that Batf3 is critical for accumulation of CD103(+) DCs in the kidney and tongue at steady state, for their expansion during systemic and oropharyngeal candidiasis, and for tissue-specific production of IL-12 in kidney but not tongue during systemic and oropharyngeal candidiasis, respectively PMID: 27191829
    8. this study shows that Batf3 promotes priming of CD8+ T cells regardless of the location of Salmonella enterica antigen PMID: 26567886
    9. Batf3 deficiency is not critical for the generation of CD8alpha dendritic cells. PMID: 25468565
    10. Data indicte that interferon regulatory factor 8 (IRF8) expression becomes dependent on transcription factor Batf3. PMID: 26054719
    11. IL-12 production by Batf3-dependent CD103+ dendritic cells is crucial for maintenance of local Th1 immunity against L. major infection. PMID: 25312824
    12. The basic leucine zipper ATF-like 3 (BATF3)- dendritic cell lineage is enriched in the lungs of asthma-protected mice and strictly required for protection. PMID: 25074917
    13. Irf8 expression in DC9 cells led to an increase in Batf3 transcript levels.When coexpressed with Irf8, Batf3 & Id2 had a synergistic effect on classical CD8alpha(+) DC development. PMID: 24227775
    14. Batf3-dependent DCs in the renal lymph node presented antigen that had been concentrated in the kidney and used PD-L1 to induce apoptosis of cytotoxic T cells PMID: 23411785
    15. A previously undescribed pathway by which CD8alpha+ Dendritic cells emerge independent of Id2, Nfil3, and Batf3, but dependent on Irf8. PMID: 23297132
    16. Defective T effector priming and resistance to experimental autoimmune encephalitis (EAE) exhibited by Csf2rb(-/-) mice does not result from the absence of dermal CD11b(low/-)Langerin(+)CD103(+) dendritic cells. PMID: 22065991
    17. study describes a transcription factor, Batf3, that controls development of CD8+ dendritic cells; dendritic cells from Batf3-/- mice were defective in cross-presentation, and Batf3-/- mice lacked virus-specific CD8+ T cell responses to West Nile virus PMID: 19008445

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    BZIP family
  • 组织特异性：
    Highly expressed in CD8-alpha(+) classical dendritic cells (cDCs), with low to absent expression in other immune cells and non-immune tissues.
  • 数据库链接：

    KEGG: mmu:381319

    STRING: 10090.ENSMUSP00000027943

    UniGene: Mm.6922