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  4. Recombinant Mouse Biogenesis of lysosome-related organelles complex 1 subunit 2 (Bloc1s2)

Recombinant Mouse Biogenesis of lysosome-related organelles complex 1 subunit 2 (Bloc1s2)

  • 中文名称：
    Recombinant Mouse Biogenesis of lysosome-related organelles complex 1 subunit 2(Bloc1s2),Yeast
  • 货号：
    CSB-YP863448MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Biogenesis of lysosome-related organelles complex 1 subunit 2(Bloc1s2),Yeast
  • 货号：
    CSB-EP863448MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Biogenesis of lysosome-related organelles complex 1 subunit 2(Bloc1s2),Yeast
  • 货号：
    CSB-EP863448MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Biogenesis of lysosome-related organelles complex 1 subunit 2(Bloc1s2),Yeast
  • 货号：
    CSB-BP863448MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Biogenesis of lysosome-related organelles complex 1 subunit 2(Bloc1s2),Yeast
  • 货号：
    CSB-MP863448MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Bloc1s2
  • Uniprot No.：
  • 别名：
    Bloc1s2; Blos2Biogenesis of lysosome-related organelles complex 1 subunit 2; BLOC-1 subunit 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-143
  • 氨基酸序列
    AAAAEGVPA TRREEQPPRD DAAVETAEEA KEPAEADINE LCRDMFSKMA TYLTGELTAT SEDYKLLENM NKLTSLKYLE MKDIAINISR NLKDLNQKYA ELQPYLDQIN MIEEQVAALE QAAYKLDAYS KKLEAKYKKL EKR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor.
  • 基因功能参考文献：
    1. BLOS2 physically interacted with Notch1 in endo-lysosomal trafficking of Notch1. The findings suggest that BLOS2 is a novel negative player in regulating Notch signaling through lysosomal trafficking to control multiple stem and progenitor cell homeostasis in vertebrates. PMID: 27719760
    2. These findings reveal that balanced control of Notch signaling by BLOS2 is required for HSC homeostasis during fetal liver hematopoiesis. PMID: 28456747
    3. SLX2 might get involved in chromosomes segregation during meiosis by interaction with BLOS2. PMID: 24870619
    4. Mutations in the human genes encoding Snapin and the BLOS proteins could underlie novel forms of Hermansky-Pudlak syndrome as seen in mouse models PMID: 15102850
  • 亚细胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Lysosome membrane.
  • 蛋白家族：
    BLOC1S2 family
  • 数据库链接：

    KEGG: mmu:73689

    STRING: 10090.ENSMUSP00000078042

    UniGene: Mm.124685